implitapide

a microsomal triglyceride transfer protein (MTP) inhibitor

Also Known As:

(2S)-2-cyclopentyl-2-(4-((2,4-dimethyl-9H-pyrido(2,3-b)indol-9-yl)methyl)phenyl)-N-((1S)-2-hydroxy-1-phenylethyl)ethanamide

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - implitapide: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - implitapide: 3

Experts

1.	Pahan, K: 1 article (05/2006)
2.	Akihisa-Umeno, Hitomi: 1 article (02/2005)
3.	Matsuo, Masahiko: 1 article (02/2005)
4.	Mutoh, Seitaro: 1 article (02/2005)
5.	Nagayoshi, Akira: 1 article (02/2005)
6.	Takakura, Shoji: 1 article (02/2005)
7.	Ueshima, Koji: 1 article (02/2005)
8.	Ito, T: 1 article (11/2001)
9.	Shiomi, M: 1 article (11/2001)

Related Diseases

1.	Homozygous Familial Hypercholesterolemia 11/09/2001 - "To examine whether a microsomal triglyceride transfer protein (MTP)-inhibitor is effective in patients with homozygous familial hypercholesterolemia, we administered (2S)-2-cyclopentyl-2-[4-[(2,4-dimethyl-9H-pyrido[2,3-b]indol-9-yl)methyl]phenyl]-N-[(1S)-2-hydroxy-1-phenylethyl]ethanamide (Implitapide), a new MTP inhibitor, to low-density lipoprotein (LDL)-receptor-deficient Watanabe heritable hyperlipidemic (WHHL) rabbits at doses of 3, 6, and 12 mg/kg for 4 weeks. "
2.	Atherosclerosis 02/01/2005 - "An MTP inhibitor, (2S)-2-cyclopentyl-2-[4-[(2,4-dimethyl-9H-pyrido[2,3-b]indol-9-yl)methyl]phenyl]-N-[(1S)-2-hydroxy-1-phenylethyl]ethanamide (implitapide), has been shown to suppress atherosclerosis in apolipoprotein E knockout (apoE KO) mice. " 02/01/2005 - "To elucidate the antiatherosclerotic mechanisms of implitapide in the mice, we examined the effects on plasma lipid levels, triglyceride (TG) elevation after oral fat loading, and development of atherosclerosis in apoE KO mice fed a Western-type diet. " 02/01/2005 - "Implitapide, a microsomal triglyceride transfer protein inhibitor, reduces progression of atherosclerosis in apolipoprotein E knockout mice fed a Western-type diet: involvement of the inhibition of postprandial triglyceride elevation."
3.	Hyperlipidemias (Hyperlipidemia) 05/01/2006 - "In addition, other drugs, such as ezetimibe, colesevelam, torcetrapib, avasimibe, implitapide, and niacin are also being considered to manage hyperlipidemia. "

Related Drugs and Biologics

1.	microsomal triglyceride transfer protein
2.	LDL Receptors (LDL Receptor)
3.	LDL Lipoproteins (beta Lipoproteins)
4.	Triglycerides (Triacylglycerol)
5.	Niacin (Nicotinic Acid)
6.	Lipids
7.	Apolipoproteins E (ApoE)
8.	Apolipoproteins
9.	Colesevelam Hydrochloride (Welchol)
10.	Ezetimibe (Zetia)