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TWEAK receptor

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a TNF receptor family member; amino acid sequence in first source

Also Known As:

Fn14 TWEAK receptor; Fn14 protein, human; Fn14 protein, mouse; Fn14 protein, rat; TNFRSF12A protein, human; TWEAK-R protein, mouse; Tnfrsf12a protein, mouse; Tnfrsf12a protein, rat; TweakR protein, human; TweakR protein, mouse; fibroblast growth factor inducible-14 protein, human; tumor necrosis factor receptor superfamily, member 12A; tumor necrosis factor receptor superfamily, member 12A protein, human; tumor necrosis factor receptor superfamily, member 12a, mouse; tumor necrosis factor receptor superfamily, member 12a, rat; tumor necrosis factor-like weak inducer of apoptosis receptor

Networked: 16 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Membrane Proteins: 5300
    - Cell Surface Receptors: 753
      - Immunologic Receptors: 8
        Cytokine Receptors: 788
        Tumor Necrosis Factor Receptors: 2575
        TWEAK receptor: 16

Experts

1.	Burkly, Linda C: 3 articles (12/2013 - 04/2005)
2.	Yagita, Hideo: 3 articles (04/2013 - 01/2002)
3.	Culp, Patricia A: 2 articles (01/2014 - 01/2010)
4.	Winkles, Jeffrey A: 2 articles (04/2013 - 10/2003)
5.	Tran, Nhan L: 2 articles (04/2013 - 11/2007)
6.	Zheng, Timothy S: 2 articles (01/2011 - 04/2005)
7.	Putterman, Chaim: 2 articles (04/2009 - 09/2004)
8.	Michaelson, Jennifer S: 2 articles (04/2009 - 04/2005)
9.	Diéras, Véronique: 1 article (01/2014)
10.	Berger, Frédérique: 1 article (01/2014)

Related Diseases

1.	Rheumatoid Arthritis 01/01/2011 - "This study aimed to investigate TWEAK and TWEAK receptor (Fn14) expression in synovial tissue from patients with active and inactive rheumatoid arthritis (RA), osteoarthritis (OA) and normal controls and assess soluble (s)TWEAK levels in the synovial fluids from patients with active RA and OA. " 10/01/2012 - "To test this, we investigated the capacity of TWEAK to induce IL-17 production in T cells via the fibroblast growth factor-inducible gene 14 (Fn14, also known as TWEAK receptor) signal pathway in rheumatoid arthritis (RA). "
2.	Osteoarthritis 01/01/2011 - "This study aimed to investigate TWEAK and TWEAK receptor (Fn14) expression in synovial tissue from patients with active and inactive rheumatoid arthritis (RA), osteoarthritis (OA) and normal controls and assess soluble (s)TWEAK levels in the synovial fluids from patients with active RA and OA. "
3.	Neoplasms (Cancer) 01/01/2014 - "In vivo PDL192 treatment had significantly anti-tumor activity in 4 of 8 TweakR-positive BC PDXs, but no correlation between the expression level of the Tweak receptor and response to therapy was observed. " 10/15/2013 - "RG7212 inhibits tumor growth in vivo in models with TWEAK receptor, Fn14, expression, and markers of pathway activation. " 10/22/2003 - "The Fn14 gene encodes a tumor necrosis-like weak inducer of apoptosis (TWEAK) receptor and is dramatically induced in DRG neurons after nerve damage, despite low expression in developing DRG neurons. " 01/15/2010 - "Antibodies to TWEAK receptor inhibit human tumor growth through dual mechanisms." 11/15/2007 - "From the list of potential targets we selected TNFRSF12A/Fn14/TWEAK receptor, a tumor necrosis factor super-family receptor, for further validation based on its reported role in tumor cell survival and potential as a target for therapy. "
4.	Necrosis 10/22/2003 - "The Fn14 gene encodes a tumor necrosis-like weak inducer of apoptosis (TWEAK) receptor and is dramatically induced in DRG neurons after nerve damage, despite low expression in developing DRG neurons. " 01/01/2006 - "Tumour necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK), a member of the TNF family, is a multifunctional cytokine that regulates cell growth, migration, and survival principally through a TWEAK receptor, fibroblast growth factor-inducible 14 (Fn14). " 01/15/2002 - "These results indicated that TWEAK could induce multiple pathways of cell death, including both caspase-dependent apoptosis and cathepsin B-dependent necrosis, in a cell type-specific manner via TWEAK receptor(s) distinct from DR3."
5.	Adenocarcinoma 11/15/2007 - "Identification of Fn14/TWEAK receptor as a potential therapeutic target in esophageal adenocarcinoma." 01/01/2005 - "We investigated TWEAK sensitivity, TWEAK effects on nuclear factor-kappaB activation, and expression of TWEAK in the HT-29, LS180, SK-CO-1 and SW480 human colonic adenocarcinoma cell lines, all of which express the TWEAK receptor (Fn14). "

Related Drugs and Biologics

1.	Fibroblast Growth Factors (Fibroblast Growth Factor)
2.	Natriuretic Peptides
3.	Interleukin-17 (Interleukin 27)
4.	Myosin Heavy Chains (Myosin Heavy Chain)
5.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6.	Proteins (Proteins, Gene)
7.	Cathepsin B
8.	Immunotoxins (Immunotoxin)
9.	Antibodies

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)