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hirsutanone

from methanolic extract of the aerial parts of Viscum cruciatum (Viscaceae)

Also Known As:

(4E)-1,7-di-(3',4'-dihydroxyphenyl)-4-hepten-3-one; 1,7-di-(3',4'-dihydroxyphenyl)-4-hepten-3-one

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Diarylheptanoids: 471
        hirsutanone: 3
  - Acyclic Hydrocarbons
    - Alkanes: 241
      - Heptanes: 70
        Diarylheptanoids: 471
        hirsutanone: 3

Experts

1.	Edoh, Dominic: 2 articles (01/2015 - 01/2014)
2.	Morinaga, Osamu: 2 articles (01/2015 - 01/2014)
3.	Shoyama, Yukihiro: 2 articles (01/2015 - 01/2014)
4.	Tung, Nguyen Huu: 2 articles (01/2015 - 01/2014)
5.	Uto, Takuhiro: 2 articles (01/2015 - 01/2014)
6.	Aning, Abigail: 1 article (01/2015)
7.	Appiah-Opong, Regina: 1 article (01/2015)
8.	Nyarko, Alexander K: 1 article (01/2015)
9.	Acero, N: 1 article (05/2014)
10.	León-Gonzalez, A J: 1 article (05/2014)

Related Diseases

1.	Neoplasms (Cancer) 05/15/2014 - "Since both compounds share similar structure and cytotoxic profile, and curcumin is in clinical trials for the treatment of cancer, our results warrant further studies to evaluate the anticancer potential of hirsutanone." 01/01/2015 - "We investigated the antiproliferative activity of hirsutanone (Hir) and oregonin (Ore) in human cancer cell lines and elucidated their mechanisms of action. " 05/15/2014 - "Our data suggest that, like curcumin, an induction of oxidative stress and topo II-mediated DNA damage may play a role in hirsutanone-induced cancer cell death. " 05/15/2014 - "Pre-treatment with the antioxidants NAC (N-acetylcysteine) and MnTMPyP (Mn(III)tetrakis-(1-methyl-4-pyridyl)porthyrin) reduced this activity, suggesting that reactive oxygen species (ROS) participate in hirsutanone-induced cancer cell death. "
2.	Leukemia 01/01/2014 - "We confirmed that oregonin (4) and hirsutanone (5) were not toxic to human normal skin fibroblast cells (NB1RGB) and colon cancer cells (HCT-15) at a concentration of 50 μM; however, lower levels of toxicity were observed for leukemia cells. "
3.	Colonic Neoplasms (Colon Cancer) 01/01/2014 - "We confirmed that oregonin (4) and hirsutanone (5) were not toxic to human normal skin fibroblast cells (NB1RGB) and colon cancer cells (HCT-15) at a concentration of 50 μM; however, lower levels of toxicity were observed for leukemia cells. "
4.	Carcinoma (Carcinomatosis) 05/15/2014 - "Hirsutanone showed cytotoxic activity against HT-29 human colon carcinoma cells. "

Related Drugs and Biologics

1.	Curcumin
2.	oregonin
3.	Reactive Oxygen Species (Oxygen Radicals)
4.	Antioxidants
5.	Acetylcysteine (Siran)
6.	Mn(III) 5,10,15,20- tetrakis(N- methylpyridinium- 2- yl)porphyrin
7.	trioctyl phosphine oxide (TOPO)