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5- (4- methylpiperazin- 1- yl)- 8- chloropyrido(2,3- b)(1,5)benzoxazepine fumarate (JL 13)

Subscribe to New Research on 5-(4-methylpiperazin-1-yl)-8-chloropyrido(2,3-b)(1,5)benzoxazepine fumarate

Also Known As:

JL 13; JL13

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds

Experts

1.	Bruhwyler, J: 2 articles (07/2001 - 03/2000)
2.	Liégeois, J F: 2 articles (07/2001 - 03/2000)
3.	Ellenbroek, Bart A: 1 article (01/2003)
4.	Liégeois, Jean-François: 1 article (01/2003)
5.	Ellenbroek, B A: 1 article (07/2001)
6.	Cools, A R: 1 article (07/2001)
7.	Zahid, N: 1 article (03/2000)
8.	Uetrecht, J: 1 article (03/2000)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 07/01/2001 - "Effects of JL13, a pyridobenzoxazepine with potential atypical antipsychotic activity, in animal models for schizophrenia." 07/01/2001 - "In the present study, JL13 was compared with clozapine and haloperidol in several animal models for schizophrenia. "
2.	Sialorrhea 01/01/2003 - "In a complex temporal regulation schedule in the dog, JL 13 showed a high resemblance with clozapine without inducing sialorrhea, palpebral ptosis or any significant motor side effects. " 10/01/1997 - "In a complex temporal regulation schedule in the dog, JL13 showed a high resemblance with clozapine without inducing sialorrhea, palpebral ptosis or any significant motor side effects. "
3.	Catalepsy 01/01/2003 - "Thus, JL 13 did not antagonize apomorphine-induced stereotypy nor did it produce catalepsy, but it antagonized apomorphine-induced climbing in rodents. " 10/01/1997 - "Like clozapine, JL13 did not antagonize apomorphine-induced stereotypy and did not produce catalepsy but antagonized apomorphine-induced climbing in rodents (ID50 = 3.9 mg kg-1 s.c.). "
4.	Dystonia (Limb Dystonia) 01/01/2003 - "Regarding behavioral toxicology, JL 13 did not produce dystonia or Parkinsonian symptoms in haloperidol-sensitized monkeys. "
5.	Agranulocytosis (Granulocytopenia) 03/01/2000 - "Thus, if, as postulated for clozapine, drug-induced agranulocytosis is due to a reactive metabolite formed by neutrophils or their precursors, JL 3 and JL 13 would not be expected to cause the same adverse reaction."

Related Drugs and Biologics

1.	Clozapine (Clozaril)
2.	Haloperidol (Haldol)
3.	Apomorphine