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3,4- dihydro- N- isopropyl- 3- (N- isopropyl- N- propylamino)- 2H- 1- benzopyran- 5- carboxamide

NAE-086 refers to the (R)-isomer; a 5-HT(1A) receptor agonist; structure in first source

Also Known As:

NAE 086; NAE-086; NAE086

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - 3,4-dihydro-N-isopropyl-3-(N-isopropyl-N-propylamino)-2H-1-benzopyran-5-carboxamide: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - 3,4-dihydro-N-isopropyl-3-(N-isopropyl-N-propylamino)-2H-1-benzopyran-5-carboxamide: 1

Experts

1.	Evenden, J L: 1 article (12/2001)
2.	Fowler, C J: 1 article (12/2001)
3.	Jerning, E: 1 article (12/2001)
4.	Kelder, D: 1 article (12/2001)
5.	Lake-Bakaar, D: 1 article (12/2001)
6.	Larsson, L G: 1 article (12/2001)
7.	Mohell, N: 1 article (12/2001)
8.	Ross, S B: 1 article (12/2001)
9.	Rënyi, L: 1 article (12/2001)
10.	Sällemark, M: 1 article (12/2001)

Related Diseases

1.

12/01/2001 - "In vivo, NAE-086 induced all the typical effects of a 5-HT(1A) receptor agonist in rats: it decreased 5-HT synthesis (5-HTP accumulation) and 5-HT turnover (measured as the ratio of 5-hydroxyindoleacetic acid/5-HT), increased corticosterone secretion, induced the 5-HT(1A) syndrome (flat body posture and forepaw treading), inhibited the cage-leaving response, and caused hypothermia. "

Related Drugs and Biologics

1.	5-HT1A Serotonin Receptor
2.	Serotonin (5 Hydroxytryptamine)
3.	Hydroxyindoleacetic Acid
4.	Corticosterone