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3- hydroxy- 17- (1H- 1,2,3- triazol- 1- yl)androsta- 5,16- diene

structure in first source

Also Known As:

3beta-hydroxy-17-(1H-1,2,3-triazol-1-yl)androsta-5,16-diene; VN 87-1

Networked: 3 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Androstanes: 11
      - Androstanols
        3-hydroxy-17-(1H-1,2,3-triazol-1-yl)androsta-5,16-diene: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Triazoles: 1533
      - 3-hydroxy-17-(1H-1,2,3-triazol-1-yl)androsta-5,16-diene: 3

Experts

1.	Brodie, Angela M H: 1 article (10/2004)
2.	Handratta, Venkatesh D: 1 article (10/2004)
3.	Jelovac, Danijela: 1 article (10/2004)
4.	Kataria, Ritesh: 1 article (10/2004)
5.	Long, Brian J: 1 article (10/2004)
6.	Njar, Vincent C O: 1 article (10/2004)
7.	Nnane, Ivo P: 1 article (10/2004)
8.	Brodie, A A: 1 article (09/2001)
9.	Njar, V C: 1 article (09/2001)
10.	Nnane, I P: 1 article (09/2001)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 10/01/1999 - "These results suggest that VN/85-1 and VN/87-1 may be potential candidates for treatment of prostate cancer." 10/01/2004 - "These results indicate that VN/85-1 or VN/87-1 may be useful in the treatment of hormone-dependent prostate cancer." 10/01/1999 - "We designed and evaluated two groups of azolyl steroids: delta5-non-competitive inhibitors (delta5NCIs), VN/63-1, VN/85-1, VN/87-1 and their corresponding delta4 derivatives (delta4NCIs), VN/107-1, VN/108-1 and VN/109-1. The human P450c17 gene was transfected into LNCaP human prostate cancer cells, and the resultant LNCaP-CYP17 cells were utilized to evaluate the inhibitory potency of the new azolyl steroids. " 10/01/2004 - "However, at their effective dosage regimes, VN/85-1 and VN/87-1 were each as effective as castration and more effective than finasteride or casodex, an anti-androgen used for prostate cancer (PC) therapy. "
2.	Neoplasms (Cancer) 09/01/2001 - "The pharmacokinetic parameters of VN/87-1 were not significantly altered in SCID mice bearing human LNCaP tumor xenografts. " 09/01/2001 - "The objective of this study was to assess the pharmacokinetics and bioavailability of 3beta-hydroxy-17-(1H-1,2,3-triazol-1-yl)androsta-5,16-diene (VN/87-1) in normal male mice and in SCID mice bearing human LNCaP tumor xenografts. " 10/01/1999 - "In this model VN/85-1 was as effective as finasteride at inhibiting tumor growth (26% and 28% inhibition, respectively) and the inhibitory effect of VN/87-1 was similar to that of castration (33% and 36% inhibition respectively). "

Related Drugs and Biologics

1.	3- hydroxy- 17- (imidazol- 1- yl)androsta- 5,16- diene
2.	Hormones (Hormone)
3.	3- hydroxy- 17- (1H- 1,2,3- triazol- 1- yl)androsta- 5,16- diene
4.	Finasteride (Propecia)
5.	Steroids
6.	Androgens
7.	bicalutamide (Casodex)

Related Therapies and Procedures

1.	Castration
2.	Therapeutics