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AICDA (activation-induced cytidine deaminase)

required enzyme for several crucial steps of B cell terminal differentiation
Also Known As:
AICDA protein; AICDA protein, human; AID enzyme, human; Aicda protein, mouse; Aicda protein, rat; CDA2 protein; activation-induced cytidine deaminase, human; activation-induced cytidine deaminase, mouse; activation-induced cytidine deaminase, rat; activation-induced cytosine deaminase, human; activation-induced deaminase (AID)
Networked: 22 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Lieber, Michael R: 3 articles (01/2022 - 01/2016)
2. Liu, Di: 2 articles (01/2022 - 01/2021)
3. Harris, Reuben S: 2 articles (06/2021 - 07/2011)
4. Chiorazzi, Nicholas: 2 articles (01/2017 - 12/2012)
5. Chu, Charles C: 2 articles (01/2017 - 12/2012)
6. MacCarthy, Thomas: 2 articles (01/2017 - 12/2012)
7. Yan, Xiao-Jie: 2 articles (01/2017 - 12/2012)
8. Pauklin, Siim: 2 articles (01/2016 - 07/2009)
9. Diaz, Marilyn: 2 articles (09/2012 - 10/2009)
10. Richter, Kathleen: 2 articles (09/2012 - 10/2009)

Related Diseases

1. Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular)
2. Human Influenza (Influenza)
3. Carcinogenesis
07/15/2009 - "Regulation of activation-induced deaminase (AID), an essential factor in Ig diversification, can alter not only somatic hypermutation and class switch recombination (CSR), but may also influence oncogenesis. "
08/01/2018 - "In this review, we discuss the linkage of activation-induced deaminase (AID)/APOBEC3 enzymes to tumorigenesis, highlight the dysregulatory mechanisms of APOBEC3 activities during cancer development, and propose potential approaches to targeting APOBEC3-mediated mutagenesis for cancer interventions."
07/29/2011 - "The beneficial effects of DNA cytidine deamination by activation-induced deaminase (AID; antibody gene diversification) and APOBEC3G (retrovirus restriction) are tempered by probable contributions to carcinogenesis. "
01/01/2016 - "Regulation of Activation Induced Deaminase (AID) by the hormone estrogen has important implications for understanding adaptive immune responses as well as the involvement of AID in autoimmune diseases and tumorigenesis. "
01/01/2017 - "Data support that (1) normal human peripheral blood cells (mononuclear cells, total lymphocytes, T as well as B lymphocytes, and NK cells) express both estrogen receptor subtypes (ERα and ERβ), (2) B-cell malignancies express mainly ERβ while selective ERβ agonists inhibit cell growth and induce apoptosis, (3) estrogens regulate, via an ER-mediated pathway, gene expression of cyclins, kinases, bcl-2 proto-oncogene, activation-induced deaminase (AID), and transcription factors, associated with changes in BCR signaling and B cell tumorigenesis. "
4. Neoplasms (Cancer)
01/01/2021 - "Analysis of translocation breakpoints in human B cell malignancies reveals that DNA double-strand breaks at oncogenes most frequently occur at CpG sites located within 20-600 bp fragile zones and depend on activation-induced deaminase (AID). "
08/01/2018 - "In this review, we discuss the linkage of activation-induced deaminase (AID)/APOBEC3 enzymes to tumorigenesis, highlight the dysregulatory mechanisms of APOBEC3 activities during cancer development, and propose potential approaches to targeting APOBEC3-mediated mutagenesis for cancer interventions."
01/01/2017 - "The targeting of mutations by Activation-Induced Deaminase (AID) is a key step in generating antibody diversity at the Immunoglobulin (Ig) loci but is also implicated in B-cell malignancies such as chronic lymphocytic leukemia (CLL). "
01/01/2017 - "Data support that (1) normal human peripheral blood cells (mononuclear cells, total lymphocytes, T as well as B lymphocytes, and NK cells) express both estrogen receptor subtypes (ERα and ERβ), (2) B-cell malignancies express mainly ERβ while selective ERβ agonists inhibit cell growth and induce apoptosis, (3) estrogens regulate, via an ER-mediated pathway, gene expression of cyclins, kinases, bcl-2 proto-oncogene, activation-induced deaminase (AID), and transcription factors, associated with changes in BCR signaling and B cell tumorigenesis. "
01/01/2018 - "Exome sequencing of Tet2-/- malignant B cells reveals C-to-T and G-to-A mutations that lie within single-stranded DNA-specific activation-induced deaminase (AID)/APOBEC (apolipoprotein B messenger RNA editing enzyme, catalytic polypeptide-like) cytidine deaminases targeted motif, as confirmed by the lack of a B-cell tumor in compound Tet2-Aicda-deficient mice. "
5. Lymphoma (Lymphomas)

Related Drugs and Biologics

1. DNA (Deoxyribonucleic Acid)
2. Immunoglobulins (Immunoglobulin)
3. Estrogens (Estrogen)
4. Enzymes
5. Cytidine
6. Uracil-DNA Glycosidase
7. A-Form DNA (A-DNA)
8. GTP Phosphohydrolases (GTPases)
9. Cyclins
10. Transcription Factors (Transcription Factor)