HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

diazepinylbenzoic acid

a retinoid x receptor and PPARgamma inhibitor

Also Known As:

HX531

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzoates: 426
        diazepinylbenzoic acid: 7
        Biphenyl Compounds: 7
        diazepinylbenzoic acid: 7
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Benzoates: 426
      - diazepinylbenzoic acid: 7

Experts

1.	Balducci, Christine: 1 article (01/2021)
2.	Boumedine, Thinhinane: 1 article (01/2021)
3.	Camelo, Serge: 1 article (01/2021)
4.	Dilda, Pierre J: 1 article (01/2021)
5.	Fontaine, Valérie: 1 article (01/2021)
6.	Fournié, Mylène: 1 article (01/2021)
7.	Guibout, Louis: 1 article (01/2021)
8.	Lafont, René: 1 article (01/2021)
9.	Latil, Mathilde: 1 article (01/2021)
10.	Monteiro, Elodie: 1 article (01/2021)

Related Diseases

1.	Inflammation (Inflammations) 12/14/2022 - "In vitro studies demonstrated that the synergistic effect of G-Rb3-FGL on FAO, oxidation and inflammation was abolished by RXRα inhibitor HX531 in the H9C2 cell model. " 01/01/2021 - "In addition, a cocktail of all three PPARs antagonists and also HX531, an antagonist of RXR reproduce norbixin effects on inflammation. " 01/01/2019 - "In OESC, PGC-1α stimulated cell proliferation and was involved in local estrogen biosynthesis, inflammation and apoptosis, and these effects of PGC-1α were inhibited by HX531. "
2.	Body Weight (Weight, Body) 05/01/2005 - "Under normal dietary conditions, 3 weeks of treatment with HX531 (0.03% and 0.06% food admixture) in KK-A y mice decreased plasma leptin levels in a dose- and time-dependent manner, in addition to decreasing body weight and mesenteric fatty tissue weight. " 04/01/2012 - "The peroxisome proliferator activated receptor-γ (PPARγ) agonist, pioglitazone (PIO), exerts anti-diabetic properties associated with increased fat mass, whereas the retinoid X receptor (RXR) antagonist HX531 demonstrates anti-obesity and anti-diabetic effects with reduced body weight and fat pad mass. "
3.	Obesity 04/01/2012 - "We conclude that HX531 exerts anti-obesity and anti-diabetes properties by up-regulating the p53-p21(Cip1) pathway, resulting in G0/G1 cell cycle arrest and the inhibition of cellular hypertrophy of adipocytes." 04/01/2012 - "The peroxisome proliferator activated receptor-γ (PPARγ) agonist, pioglitazone (PIO), exerts anti-diabetic properties associated with increased fat mass, whereas the retinoid X receptor (RXR) antagonist HX531 demonstrates anti-obesity and anti-diabetic effects with reduced body weight and fat pad mass. "
4.	Neuroblastoma 01/04/2007 - "Pre-incubation of SH-SY5Y human neuroblastoma cells with either RAR-pan-antagonist LE540 or MAP kinase kinase 1 (MEK-1) inhibitor PD98059 resulted in the abolition of ATRA-induced COX-2 promoter activity, COX-2 protein expression and PGE2 production whereas the retinoid X receptor pan-antagonist HX531, the p38 MAPK inhibitor SB203580 or the c-Jun kinase inhibitor SP600125 did not have any effect. "
5.	Leukemia 12/19/1997 - "In human HL-60 promyelocytic leukemia cells, diazepinylbenzoic acid derivatives can exhibit either antagonistic or synergistic effects on the differentiation-inducing activities of natural or synthetic retinoids, the activity depending largely on the nature of the substituents on the diazepine ring. "

Related Drugs and Biologics

1.	Retinoid X Receptors (Retinoid X Receptor)
2.	MAP Kinase Kinase 1
3.	p38 Mitogen-Activated Protein Kinases
4.	Peroxisome Proliferator-Activated Receptors (PPAR)
5.	Leptin
6.	Dinoprostone (PGE2)
7.	Retinoids
8.	Proteins (Proteins, Gene)
9.	Phosphotransferases (Kinase)
10.	Estrogens (Estrogen)