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6-methoxydihydrosanguinarine

from Corydalis tashiroi (Fumariaceae); structure in first source

Also Known As:

6-methoxydihydro-sanguinarine

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Benzophenanthridines
    - 6-methoxydihydrosanguinarine: 4
- Fused-Ring Heterocyclic Compounds

Experts

1.	Kim, Young-Ho: 1 article (12/2004)
2.	Lee, Byung-Hoon: 1 article (12/2004)
3.	Lee, Yong-Jin: 1 article (12/2004)
4.	Li, Guang-Yong: 1 article (12/2004)
5.	Yin, Hu-Quan: 1 article (12/2004)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 01/01/2023 - "6-Methoxydihydrosanguinarine induces apoptosis and autophagy in breast cancer MCF-7 cells by accumulating ROS to suppress the PI3K/AKT/mTOR signaling pathway." 10/01/2022 - "Among them, the undescribed alkaloids 6S/R-acroleinyl-dihydrochelerythrine, 6,10-dimethoxydihydrochelerythrine, 6-ethoxy-ethaniminyl-dihydrochelandine, 9-methoxy-10-hydroxy-norchelerythrine and other known alkaloids 6-methoxydihydrosanguinarine, 6-acetaldehyde-dihyrochelerythrine, dihydrosanguinaline and 10-methoxy boconoline had good inhibitory effects on MCF-7 cells of breast cancer with an IC50 lower than 20 μM."
2.	Hepatocellular Carcinoma (Hepatoma) 08/11/2023 - "6-Methoxydihydrosanguinarine exhibits cytotoxicity and sensitizes TRAIL-induced apoptosis of hepatocellular carcinoma cells through ROS-mediated upregulation of DR5."
3.	Carcinoma (Carcinomatosis) 12/01/2004 - "Apoptosis inducing effects of 6-methoxydihydrosanguinarine in HT29 colon carcinoma cells." 12/01/2004 - "6-methoxydihydrosanguinarine (6ME), a benzophenanthridine alkaloid derived from the methanol extracts of Hylomecon hylomeconoides, showed a dose-dependent effect at 1-10 microM on causing apoptotic cell death in HT29 colon carcinoma cells (IC50 = 5.0+/-0.2 microM). "

Related Drugs and Biologics

1.	Alkaloids
2.	Methanol (Carbinol)
3.	dihydrochelerythrine