NK3201

inhibits vascular proliferation in grafted vein

Also Known As:

(2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-(3,4-dioxo-1-phenyl-7-(2-pyridyloxy)-2-heptyl)acetamide); NK 3201

Networked: 10 relevant articles (1 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Acetamides: 21
    - NK3201: 10
- Carboxylic Acids: 973
  - Acyclic Acids
    - Acetates: 4994
      - Acetamides: 21
        NK3201: 10
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - NK3201: 10

Experts

1.	Miyazaki, Mizuo: 9 articles (07/2009 - 11/2002)
2.	Takai, Shinji: 9 articles (07/2009 - 11/2002)
3.	Jin, Denan: 7 articles (07/2009 - 02/2003)
4.	Muramatsu, Michiko: 4 articles (04/2007 - 06/2004)
5.	Sakaguchi, Masato: 4 articles (04/2005 - 02/2003)
6.	Nishimoto, Masayoshi: 2 articles (04/2007 - 06/2004)
7.	Okamoto, Yukiko: 2 articles (04/2005 - 06/2004)
8.	Kamoshita, Keiichi: 2 articles (02/2003 - 11/2002)
9.	Sukenaga, Yoshikazu: 2 articles (02/2003 - 11/2002)
10.	Lu, Zhongyi: 1 article (06/2017)

Related Diseases

1.	Neointima 04/01/2005 - "In association with the reduction of chymase expression, a marked decrease in Ang II-, AT(1) receptor-, and TGF-beta-positive areas was achieved by NK3201 (a chymase inhibitor) treatment, and the neointima formation (intima/media: region A, 53 +/- 9%, P < 0.001; region B, 54 +/- 14%, P < 0.001) was also significantly suppressed in this group. "
2.	Abdominal Aortic Aneurysm 04/01/2007 - "In this study, we investigated the effect of a specific chymase inhibitor, NK3201, in the progression of abdominal aortic aneurysm in a dog experimental model. " 06/01/2004 - "In this study, we investigated the effect of a specific chymase inhibitor, 2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[3,4-dioxo-1-phenyl-7-(2-pyridyloxy)]-2-heptyl]acetamide (NK3201), in the development of abdominal aortic aneurysm in a hamster experimental model. " 06/01/2004 - "A specific chymase inhibitor, 2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[3,4-dioxo-1-phenyl-7-(2-pyridyloxy)]-2-heptyl]acetamide (NK3201), suppresses development of abdominal aortic aneurysm in hamsters."
3.	Hyperplasia 02/01/2003 - "A novel chymase inhibitor, 2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[,4-dioxo-1-phenyl-7-(2-pyridyloxy)]2-heptyl]acetamide (NK3201), suppressed intimal hyperplasia after balloon injury." 11/01/2002 - "Recently, however, the chymase inhibitor NK3201 (2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidin-1-yl)-N-[[3,4-dioxo-1-phenyl-7-(2-pyridyloxy)]-2-heptyl] acetamide) was demonstrated to have oral activity against neointimal hyperplasia in dog models (Takai S. " 02/01/2003 - "In this study, we investigated whether an orally active chymase inhibitor, 2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[3,4-dioxo-1-phenyl-7-(2-pyridyloxy)]-2-heptyl]acetamide (NK3201), prevents intimal hyperplasia in carotid arteries injured by a balloon catheter in dog. "
4.	Lung Injury 06/01/2017 - "This study suggested that the AngII-p22phox-ROS signaling pathway, PPARγ and OGG1 together contributed to the hyperoxia-induced lung injury and that NK3201 was able to reverse the effects of hyperoxia."
5.	Ventricular Remodeling 07/01/2009 - "The aim of this study was to evaluate the effect of a novel chymase inhibitor (NK3201) on hypoxia-induced left ventricular remodeling in mice. "

Related Drugs and Biologics

1.	Chymases (Chymase)
2.	Transforming Growth Factor beta (TGF-beta)
3.	acetamide
4.	Bleomycin (Blenoxane)
5.	Angiotensin II
6.	Caspase 3 (Caspase-3)
7.	Proteins (Proteins, Gene)
8.	chymotrypsin inhibitor 2

Related Therapies and Procedures

1.	Catheters
2.	Ligation