nemorosone

01/15/2015 - "In comparison to breast cancer cells without treatment, nemorosone induced discrete cell cycle arrest in the G1 phase and significant depletion in the G2 phase. "
01/15/2015 - "Effects of nemorosone, isolated from the plant Clusia rosea, on the cell cycle and gene expression in MCF-7 BUS breast cancer cell lines."
07/31/2013 - "These findings suggest that nemorosone may have therapeutic application in the treatment of breast cancer."
01/01/2011 - "These findings suggest that nemorosone may have therapeutic application in the treatment of breast cancer because of its activity on ERα."
01/01/2011 - "Cytotoxic activity of nemorosone in human MCF-7 breast cancer cells."

11/15/2012 - "The aim of this work was to characterize the antitumoral activity of the plant compound 7-epi-nemorosone in prostate carcinoma cell lines. "
07/01/2019 - "In summary, our findings evidence the potential role of Cuban propolis extracts and their main component nemorosone as new chemosensitizing agents against drug-resistant human colon carcinoma cells."
11/15/2012 - "7-epi-nemorosone from Clusia rosea induces apoptosis, androgen receptor down-regulation and dysregulation of PSA levels in LNCaP prostate carcinoma cells."
03/01/2002 - "We found that nemorosone has cytotoxic activity against epitheloid carcinoma (HeLa), epidermoid carcinoma (Hep-2), prostate cancer (PC-3) and central nervous system cancer (U251). "
07/01/2019 - "Combination experiments were carried out in order to study the ability of Cuban propolis extracts (CP) and its main component (nemorosone) to chemosensitize doxorubicin-resistant human colon carcinoma cells (LoVo Dox) compared to the sensitive cells (LoVo). "

01/01/2023 - "Here, we identified the natural mitochondrial uncoupler nemorosone as a ferroptosis inducer in cancer cells. "
01/01/2023 - "Molecular Mechanisms of Nemorosone-Induced Ferroptosis in Cancer Cells."
07/31/2013 - "Nemorosone has received increasing attention due to its strong in vitro anti-cancer action. "
03/01/2011 - "Therefore, nemorosone is a new potent protonophoric mitochondrial uncoupler and this property is potentially involved in its toxicity on cancer cells."
03/01/2011 - "Nemorosone, a natural-occurring polycyclic polyprenylated acylphloroglucinol, has received increasing attention due to its strong in vitro anti-cancer action. "

01/01/2013 - "At a dose of 50 mg/kg nemorosone per day, a significant growth-inhibitory effect was observed in pancreatic cancer xenografts. "
01/01/2013 - "Thus, we investigated the growth-inhibitory potential of nemorosone on pancreatic cancer xenografts in NMRI nu/nu mice and determined basic pharmacokinetic parameters. "
01/01/2013 - "In vivo activity and pharmacokinetics of nemorosone on pancreatic cancer xenografts."
03/01/2011 - "Microarray analysis of nemorosone-induced cytotoxic effects on pancreatic cancer cells reveals activation of the unfolded protein response (UPR)."
03/01/2011 - "Nemorosone cytotoxicity was assessed by the resazurin proliferation assay on pancreatic cancer cells and fibroblasts. "

08/01/2008 - "Nemorosone proved cytotoxic in both parental and chemoresistant leukemia cell lines with IC50 values between 2.10 and 3.10 mg/ml. No cross-resistances could be detected. "
08/01/2008 - "Nemorosone blocks proliferation and induces apoptosis in leukemia cells."
08/01/2008 - "Here, we demonstrate for the first time that nemorosone exerts cytotoxicity in leukemia cells, partly by targeting the Akt/PKB signal transducer, affecting protein levels and cell cycle progression. "
10/15/2019 - "Here we investigated the symbiotic relationship between monocytic leukemia THP-1 and hepatocellular carcinoma HepG2 cells, and the role of nemorosone in preventing TAM-induced tumor growth. "