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tetra(3-hydroxyphenyl)porphine

structure in first source

Also Known As:

mTHPP; meso-tetra(3-hydroxyphenyl)porphine

Networked: 8 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ding, Huiying: 2 articles (10/2011 - 07/2010)
2.	Gao, Jinming: 2 articles (10/2011 - 07/2010)
3.	Sumer, Baran D: 2 articles (10/2011 - 07/2010)
4.	Buchholz, Rebecca: 1 article (09/2016)
5.	Grünebaum, Jonas: 1 article (09/2016)
6.	Karst, Uwe: 1 article (09/2016)
7.	Kröger, Sabrina: 1 article (09/2016)
8.	Langer, Klaus: 1 article (09/2016)
9.	Moosmann, Aline: 1 article (09/2016)
10.	Mulac, Dennis: 1 article (09/2016)

Related Diseases

1.	Head and Neck Neoplasms (Head and Neck Cancer) 10/01/2011 - "Characterization and optimization of mTHPP nanoparticles for photodynamic therapy of head and neck cancer." 07/01/2010 - "To encapsulate 5,10,15,20-tetrakis(meso-hydroxyphenyl)porphyrin (mTHPP), a photosensitizer, into polymeric micelles; characterize the micelles; and test in vitro photodynamic therapy efficacy against human head and neck cancer cells. " 10/01/2011 - "To characterize the properties of polymeric micelles containing different loading percentages of mTHPP, a photosensitizer for photodynamic therapy (PDT), with respect to fluorescence, singlet oxygen ((1)O(2)) yield, and in vitro cytotoxicity in head and neck cancer cells. "
2.	Experimental Melanoma 01/01/2022 - "The PDT efficacy of the QDs, mTHPP, and conjugate was evaluated against the murine metastatic melanoma (B16 F10 Nex2) cell line. "
3.	Neoplasms (Cancer) 08/01/2001 - "The tumor localizing properties of mTHPP and mTHPC reported in the literature appear to be due to factors other than pH-dependent changes in the lipophilicity of the drugs." 09/28/2016 - "To investigate drug penetration, tumor spheroids were incubated with platinum complexes (Pt(II)acetylacetonate, cisplatin) and the palladium tagged photosensitizer 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin (mTHPP). "
4.	Phototoxic Dermatitis (Phototoxicity) 07/01/2010 - "Significant cytotoxicity was observed with confocal microscopy when HSC-3 cells were treated with 10 percent mTHPP micelles, with 100 percent cytotoxicity within the zone of laser light exposure at 420 nm. Phototoxicity and dark toxicity against HSC-3 and HN-5 cells measured using the MTT assay with five and 10 percent loaded mTHPP micelles demonstrated greater than 90 percent cytotoxicity with photodynamic therapy and less than 10 percent dark toxicity at a micelle concentration of 25 microg/mL for both cell lines. "
5.	Rupture 04/13/2015 - "Upon irradiation, the porphyrin core of mTHPP-βCD expedited endosomal membrane rupture and tamoxifen release into the cytosol, as documented by confocal microscopy. "

Related Drugs and Biologics

1.	Photosensitizing Agents (Photosensitizers)
2.	Micelles
3.	1-phenyl-3,3-dimethyltriazene (PDT)
4.	Singlet Oxygen
5.	Tamoxifen
6.	Porphyrins
7.	Platinum
8.	Palladium
9.	Cyclodextrins
10.	Cisplatin (Platino)

Related Therapies and Procedures

1.	Photochemotherapy (Photodynamic Therapy)
2.	Lasers (Laser)