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9- carboxymethyl- 4- oxo- 5H,10H- imidazo(1,2- a)indeno(1,2- e)pyrazin- 2- phosphonic acid

strucure in first source

Also Known As:

RPR 119990; RPR119990

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - 9-carboxymethyl-4-oxo-5H,10H-imidazo(1,2-a)indeno(1,2-e)pyrazin-2-phosphonic acid: 2
  - Pyrazines: 150
    - 9-carboxymethyl-4-oxo-5H,10H-imidazo(1,2-a)indeno(1,2-e)pyrazin-2-phosphonic acid: 2

Experts

1.	Barbera, Sara: 1 article (03/2006)
2.	Bigini, Paolo: 1 article (03/2006)
3.	De Paola, Massimiliano: 1 article (03/2006)
4.	Fumagalli, Elena: 1 article (03/2006)
5.	Mennini, Tiziana: 1 article (03/2006)
6.	Alavijeh, M: 1 article (10/2001)
7.	Boireau, A: 1 article (10/2001)
8.	Bordier, F: 1 article (10/2001)
9.	Brealey, C: 1 article (10/2001)
10.	Briet, D: 1 article (10/2001)

Related Diseases

1.	Neurodegenerative Diseases (Neurodegenerative Disease) 03/01/2006 - "Riluzole, unlike the AMPA antagonist RPR119990, reduces motor impairment and partially prevents motoneuron death in the wobbler mouse, a model of neurodegenerative disease."
2.	Muscular Atrophy (Muscle Atrophy) 03/01/2006 - "Chronic treatment with the AMPA antagonist RPR119990 is ineffective in improving motor impairment, in reducing motoneuronal loss and muscular atrophy in treated mice. "
3.	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 10/01/2001 - "RPR 119990, a novel alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid antagonist: synthesis, pharmacological properties, and activity in an animal model of amyotrophic lateral sclerosis."

Related Drugs and Biologics

1.	alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)
2.	Riluzole