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(2- ((pentafluorophenylmethyl)hydroxyphosphinyl) methyl)pentanedioic acid
N-acetylated-alpha-linked acidic dipeptidase (NAALADase) inhibitor; structure in first source
Also Known As:
GPI5232
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Benzene Derivatives: 17
Fluorobenzenes: 14
(2-((pentafluorophenylmethyl)hydroxyphosphinyl) methyl)pentanedioic acid: 1
Halogenated Hydrocarbons: 42
Fluorinated Hydrocarbons: 4
Fluorocarbons: 1209
(2-((pentafluorophenylmethyl)hydroxyphosphinyl) methyl)pentanedioic acid: 1
Fluorobenzenes: 14
(2-((pentafluorophenylmethyl)hydroxyphosphinyl) methyl)pentanedioic acid: 1
Carboxylic Acids: 973
Acyclic Acids
Dicarboxylic Acids: 108
Glutarates: 35
(2-((pentafluorophenylmethyl)hydroxyphosphinyl) methyl)pentanedioic acid: 1
Experts
1.
Lu, X M
: 1 article (10/2001)
2.
Slusher, B
: 1 article (10/2001)
3.
Tortella, F C
: 1 article (10/2001)
4.
Williams, A J
: 1 article (10/2001)
Related Diseases
1.
Brain Infarction
10/01/2001 - "
Continuous i.v. infusion of GPI5232 starting 1 h after injury resulted in more than a 50% reduction in brain infarct volume caused by 2 h of MCAo.
"
10/01/2001 - "
These results show GPI5232 to be an effective neuroprotective treatment when given postinjury by reducing brain infarction and ameliorating the pathological EEG associated with focal brain ischemia.
"
2.
Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
10/01/2001 - "
We have evaluated the effects of the N-acetylated-alpha-linked acidic dipeptidase (NAALADase) inhibitor, GPI5232 [2-[(pentafluorophenylmethyl)hydroxyphosphinyl]methyl)-pentanedioic acid], to not only decrease brain injury but also to alter the inherent electroencephalographic (EEG) changes observed in a rat model of transient middle cerebral artery occlusion (MCAo).
"
3.
Seizures (Absence Seizure)
10/01/2001 - "
MCAo-injured rats were also predisposed to developing cortical brain seizures, and GPI5232-treated rats had significantly fewer brain seizures than vehicle-treated animals.
"
4.
Brain Ischemia (Cerebral Ischemia)
10/01/2001 - "
These results show GPI5232 to be an effective neuroprotective treatment when given postinjury by reducing brain infarction and ameliorating the pathological EEG associated with focal brain ischemia.
"
5.
Brain Injuries (Brain Injury)
10/01/2001 - "
We have evaluated the effects of the N-acetylated-alpha-linked acidic dipeptidase (NAALADase) inhibitor, GPI5232 [2-[(pentafluorophenylmethyl)hydroxyphosphinyl]methyl)-pentanedioic acid], to not only decrease brain injury but also to alter the inherent electroencephalographic (EEG) changes observed in a rat model of transient middle cerebral artery occlusion (MCAo).
"
Related Drugs and Biologics
1.
Glutamate Carboxypeptidase II (N-Acetylaspartylglutamate Peptidase)
2.
Acids