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methyl 3,5-diiodo-4-(4'-methoxyphenoxy)benzoate

a tubulin-binding agent; structure in first source

Also Known As:

BTO 956; BTO-956; BTO956; methyl-3,5-diiodo-4-(4'-methoxyphenoxy)benzoate

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzoates: 426
        Iodobenzoates
        methyl 3,5-diiodo-4-(4'-methoxyphenoxy)benzoate: 2
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Benzoates: 426
      - Iodobenzoates
        methyl 3,5-diiodo-4-(4'-methoxyphenoxy)benzoate: 2

Experts

1.	Cui, Zheng-Guo: 1 article (01/2021)
2.	Feng, Qian-Wen: 1 article (01/2021)
3.	Hiraku, Yusuke: 1 article (01/2021)
4.	Inadera, Hidekuni: 1 article (01/2021)
5.	Li, Yu-Lin: 1 article (01/2021)
6.	Sun, Lu: 1 article (01/2021)
7.	Wu, Cheng-Ai: 1 article (01/2021)
8.	Zakki, Shahbaz Ahmad: 1 article (01/2021)
9.	Zhou, De-Jun: 1 article (01/2021)
10.	Dewhirst, M W: 1 article (08/2001)

Related Diseases

1.	Corneal Neovascularization 08/01/2001 - "BTO-956 significantly inhibited corneal angiogenesis (by 50-80%), as assessed by measurements of limbal circumference displaying neovascularization, vessel length, vascularized area, and vascular area density. " 08/01/2001 - "Here we report that BTO-956 given to Fischer 344 rats also inhibits corneal angiogenesis and the growth and neovascularization of the R3230Ac rat mammary carcinoma tumor implanted in skin-fold window chambers. "
2.	Neoplasms (Cancer) 08/01/2001 - "BTO-956 was given during days 5-11, and images of the tumors and their vasculature were recorded on day 12. " 08/01/2001 - "Together, these findings demonstrate that BTO-956 can inhibit angiogenesis induced by a growth factor in the rat cornea and in the peripheral area of implanted tumors, where tumor angiogenesis is most active." 08/01/2001 - "Here we report that BTO-956 given to Fischer 344 rats also inhibits corneal angiogenesis and the growth and neovascularization of the R3230Ac rat mammary carcinoma tumor implanted in skin-fold window chambers. "
3.	Lymphoma (Lymphomas) 01/01/2021 - "The molecular mechanism of a novel derivative of BTO-956 induced apoptosis in human myelomonocytic lymphoma cells."
4.	Carcinoma (Carcinomatosis) 08/01/2001 - "The novel tubulin-binding drug BTO-956 inhibits R3230AC mammary carcinoma growth and angiogenesis in Fischer 344 rats." 08/01/2001 - "Here we report that BTO-956 given to Fischer 344 rats also inhibits corneal angiogenesis and the growth and neovascularization of the R3230Ac rat mammary carcinoma tumor implanted in skin-fold window chambers. " 08/01/2001 - "BTO-956 [methyl-3,5-diiodo-4-(4'-methoxyphenoxy)benzoate], a novel tubulin-binding drug and thyroid hormone analogue, was originally found to inhibit human carcinoma cell proliferation in vitro and to have potent growth delay activity in human breast and ovarian carcinoma xenografts in nude mice. "

Related Drugs and Biologics

1.	Intercellular Signaling Peptides and Proteins (Growth Factors)
2.	Tubulin
3.	Thyroid Hormones
4.	Benzoates (Benzoate)