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2,7-dibromocryptolepine

a quindoline or fused indole-quinoline; structure in first source

Also Known As:

2,7-dibromo-cryptolepine; 2,7-dibromo-5H-quindoline, 5-methyl-

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - 2,7-dibromocryptolepine: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - 2,7-dibromocryptolepine: 3
    - Quinolines: 146
      - 2,7-dibromocryptolepine: 3

Experts

1.	Shnyder, Steven D: 2 articles (01/2022 - 04/2005)
2.	Wright, Colin W: 2 articles (01/2022 - 04/2005)
3.	Abacha, Yabalu Z: 1 article (01/2022)
4.	Birkholtz, Lyn-Marie: 1 article (01/2022)
5.	Cockcroft, Jeremy K: 1 article (01/2022)
6.	Forkuo, Arnold Donkor: 1 article (01/2022)
7.	Gbedema, Stephen Y: 1 article (01/2022)
8.	Kelly, John M: 1 article (01/2022)
9.	Lisgarten, David R: 1 article (01/2022)
10.	Lisgarten, John N: 1 article (01/2022)

Related Diseases

1.	Parasitemia 04/07/2005 - "2,7-Dibromocryptolepine (15) was evaluated at several dose levels, and a dose-dependent suppression of parasitemia was seen (ED(90) = 21.6 mg kg(-1) day(-1)). " 09/13/2001 - "Several compounds also displayed activity against Plasmodium berghei in mice, the most potent being 2,7-dibromocryptolepine 8, which suppressed parasitemia by 89% as compared to untreated infected controls at a dose of 12.5 mg kg(-1) day(-1) ip. "
2.	Malaria 01/01/2022 - "The West African climbing shrub Cryptolepis sanguinolenta is used traditionally for the treatment of malaria; its principal alkaloid, cryptolepine (1), has been shown to have antimalarial properties, and the synthetic analogue 2,7-dibromocryptolepine (2) is of interest as a lead toward new antimalarial agents. "

Related Drugs and Biologics

1.	Antimalarials (Antimalarial Agents)
2.	Alkaloids
3.	cryptolepine