Trace amine-associated receptor 1

potential direct targets for drugs of abuse; binds beta-phenylethylamine and TYRAMINE

Also Known As:

TA1 amine receptor; TAAR1 protein, human; TAR-1 protein, human; TAR1 protein, human; TRAR1 protein, human; Taar1 protein, mouse; Taar1 protein, rat; Trace amine receptor 1; trace amine associated receptor 1, human; trace amine-associated receptor 1, mouse; trace-amine-associated receptor 1, rat

Networked: 56 relevant articles (4 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - G-Protein-Coupled Receptors: 4701
        Trace amine-associated receptor 1: 56

Experts

1.	Hopkins, Seth C: 6 articles (01/2022 - 01/2020)
2.	Koblan, Kenneth S: 6 articles (01/2022 - 01/2020)
3.	Li, Jun-Xu: 6 articles (01/2022 - 10/2014)
4.	Zhang, Yanan: 4 articles (01/2022 - 10/2014)
5.	Dedic, Nina: 3 articles (01/2022 - 01/2021)
6.	Wu, Ruyan: 3 articles (01/2022 - 12/2021)
7.	Rutigliano, Grazia: 3 articles (01/2021 - 01/2019)
8.	Hoener, Marius C: 3 articles (01/2019 - 01/2016)
9.	Liu, Jianfeng: 2 articles (01/2022 - 01/2022)
10.	Goldman, Robert: 2 articles (12/2021 - 01/2020)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 07/13/2023 - "Trace amine-associated receptor 1 is emerging as a new therapeutic target for schizophrenia and several other neuropsychiatric disorders. " 05/01/2023 - "Evidence has accumulated on trace amine-associated receptor 1 (TAAR1) as a novel therapeutic target for treating schizophrenia. " 01/01/2023 - "As preclinical and clinical research progresses, trace amine-associated receptor 1 (TAAR1) is becoming a potential new target for the treatment of schizophrenia. " 01/01/2023 - "Trace amine-associated receptor 1 (TAAR1) agonism as a new treatment strategy for schizophrenia and related disorders." 09/01/2022 - "A New Treatment Paradigm: Targeting Trace Amine-Associated Receptor 1 (TAAR1) in Schizophrenia."
2.	Psychotic Disorders (Schizoaffective Disorder) 09/30/2022 - "Discovery and In Vivo Efficacy of Trace Amine-Associated Receptor 1 (TAAR1) Agonist 4-(2-Aminoethyl)-N-(3,5-dimethylphenyl)piperidine-1-carboxamide Hydrochloride (AP163) for the Treatment of Psychotic Disorders." 11/07/2022 - "Discovery of Trace Amine Associated Receptor 1 (TAAR1) Agonist 2-(5-(4'-Chloro-[1,1'-biphenyl]-4-yl)-4H-1,2,4-triazol-3-yl)ethan-1-amine (LK00764) for the Treatment of Psychotic Disorders." 08/01/2023 - "Ulotaront, a Trace Amine-Associated Receptor 1/Serotonin 5-HT1A Agonist, in Patients With Parkinson Disease Psychosis: A Pilot Study." 01/01/2020 - "An oral compound, SEP-363856, that does not act on dopamine D2 receptors but has agonist activity at trace amine-associated receptor 1 (TAAR1) and 5-hydroxytryptamine type 1A (5-HT1A) receptors, may represent a new class of psychotropic agent for the treatment of psychosis in schizophrenia. "
3.	Mental Disorders (Mental Disorder) 01/01/2021 - "As one of the GPCRs, trace amine-associated receptor 1 (TAAR1) has recently aroused increasing interest as a potential therapeutic target for psychiatric disorders. " 01/01/2019 - "Non-Functional Trace Amine-Associated Receptor 1 Variants in Patients With Mental Disorders." 05/01/2023 - "Efficacy, safety, and tolerability of ulotaront (SEP-363856, a trace amine-associated receptor 1 agonist) for the treatment of schizophrenia and other mental disorders: a systematic review of preclinical and clinical trials."
4.	Cocaine-Related Disorders (Cocaine Addiction) 01/01/2022 - "Recent studies suggested that the trace amine-associated receptor 1 (TAAR1) could be a promising target to treat cocaine addiction and relapse; however, the underlying mechanism remains unclear. " 10/31/2014 - "Trace amine associated receptor 1 is implicated in cocaine addiction and represents a potential therapeutic target. "
5.	Neurobehavioral Manifestations 09/01/2022 - "Recently, a phase 2 clinical trial and extension study demonstrated that, relative to placebo, the trace amine-associated receptor 1 (TAAR1) agonist ulotaront was effective at controlling the positive, negative, and cognitive symptoms of schizophrenia. "

Related Drugs and Biologics

1.	SEP-363856
2.	Serotonin (5 Hydroxytryptamine)
3.	5-HT1A Serotonin Receptor
4.	Dopamine (Intropin)
5.	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)
6.	Serotonin 5-HT1 Receptor Agonists
7.	Dopamine D2 Receptors (Dopamine D2 Receptor)
8.	Antipsychotic Agents (Antipsychotics)
9.	Glucose (Dextrose)
10.	Amines

Related Therapies and Procedures

1.	Therapeutics
2.	Glycemic Control