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GW 3333

inhibits both TNF-alpha-converting enzyme and matrix metalloproteinases; structure in first source

Also Known As:

GW-3333; GW3333

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Aminopyridines: 77
    - GW 3333: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Aminopyridines: 77
      - GW 3333: 2
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - Dipeptides: 945
      - GW 3333: 2

Experts

1.	Doggrell, Sheila A: 1 article (07/2002)
2.	Andrews, R C: 1 article (09/2001)
3.	Beaudet, B: 1 article (09/2001)
4.	Becherer, J D: 1 article (09/2001)
5.	Bickett, D M: 1 article (09/2001)
6.	Boncek, V: 1 article (09/2001)
7.	Brodie, T A: 1 article (09/2001)
8.	Clark, R L: 1 article (09/2001)
9.	Conway, J G: 1 article (09/2001)
10.	Crumrine, R C: 1 article (09/2001)

Related Diseases

1.

Arthritis (Polyarthritis)

07/01/2002 - "In rat models of arthritis, GW3333 has some beneficial effects. "
09/01/2001 - "GW3333, a dual inhibitor of TACE and matrix metalloproteinases (MMPs), was compared with an anti-TNF antibody to evaluate the importance of soluble TNF and MMPs in rat models of arthritis. "
09/01/2001 - "Inhibition of tumor necrosis factor-alpha (TNF-alpha) production and arthritis in the rat by GW3333, a dual inhibitor of TNF-alpha-converting enzyme and matrix metalloproteinases."

Related Drugs and Biologics

1.	Matrix Metalloproteinases (MMPs)
2.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
3.	ADAM17 Protein