lomaiviticin A

antitumor antibiotics from Micromonospora lomaivitiensis; benzo[a]fluorene related to kinamycins

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

1.	Neoplasms (Cancer) 03/15/2016 - "(-)-Lomaiviticin A (1) is a complex antiproliferative metabolite that inhibits the growth of many cultured cancer cell lines at low nanomolar-picomolar concentrations. " 10/17/2017 - "Additionally, (-)-lomaiviticin A (4) is a potent cytotoxin, with half-maximal inhibitory potency (IC50) values in the low nanomolar range against many cancer cell lines. " 06/01/2014 - "The metabolite (-)-lomaiviticin A, which contains two diazotetrahydrobenzo[b]fluorene (diazofluorene) functional groups, inhibits the growth of cultured human cancer cells at nanomolar-picomolar concentrations; however, the mechanism responsible for the potent cytotoxicity of this natural product is not known. "
2.	Ataxia Telangiectasia (Louis Bar Syndrome) 01/01/2016 - "Here we show that the cytotoxicity of (-)-lomaiviticin A (1) is synergistically potentiated in the presence of VE-821 (7), an inhibitor of ataxia telangiectasia and Rad3-related protein (ATR). "

1.	Proteins (Proteins, Gene)
2.	Cytotoxins (Cytolysins)
3.	3- amino- 6- (4- (methylsulfonyl)phenyl)- N- phenylpyrazine- 2- carboxamide
4.	fluorene