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MW167

fluoromethyl ketone psuedopeptide analogue; Boc-Val-Ile-ketone-Val-Ile, a gamma-secretase inhibitor;

Also Known As:

MW167 cpd

Networked: 5 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - MW167: 5

Experts

1.	Liang, Mulin: 1 article (04/2019)
2.	Lu, Xue: 1 article (04/2019)
3.	Wang, Chao: 1 article (04/2019)
4.	Xiao, Changxue: 1 article (04/2019)
5.	Xu, Feng: 1 article (04/2019)
6.	Zhang, Chao: 1 article (04/2019)
7.	Liu, Liangxiao: 1 article (08/2017)
8.	Wang, Haiying: 1 article (08/2017)
9.	Wu, Fuling: 1 article (08/2017)
10.	Zhang, Xuejing: 1 article (08/2017)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2015 - "MW167 treatment prevented OVA-induced airway inflammation and histological changes. " 01/01/2015 - "The present study aimed to investigate the role of GSI MW167 in T cell differentiation and antigen-induced airway inflammation. " 01/01/2015 - "Our findings indicate that Notch signalling plays an important role in the pathogenesis of asthma and that MW167 may be a potential therapeutic target for allergen-induced airway inflammation. "
2.	Bronchiolitis 08/01/2017 - "Objective To study the changes of GATA3 in peripheral blood mononuclear cells (PBMCs) of children with respiratory syncytial virus (RSV) bronchiolitis after γ-secretase inhibitor (GSI) MW167 blocks Notch signaling. " 08/01/2017 - "[γ-secretase inhibitor MW167 reduces the level of GATA3 in peripheral blood mononuclear cells in children with respiratory syncytial virus bronchiolitis]."
3.	Hyperoxia 04/01/2019 - "According to the proteomic results, AEC II were divided into three groups: normoxia group, hyperoxia group and hyperoxia+MW167 group (γ-secretase inhibitor MW167 was added to culture medium 30 minutes before they were placed into the chamber). "
4.	Lung Neoplasms (Lung Cancer) 10/01/2016 - "MTT assay and colony forming assay were used to detect the effects of different doses of X-rays and MW167 on the in vitro proliferation of the lung cancer cell line H358. "
5.	Food Hypersensitivity (Food Allergy) 01/01/2017 - "An ovalbumin-induced food allergy mouse model was built (cholera toxin as adjuvant) and Notch signaling was blunted by FLI-06 and MW167, which inhibited Notch receptor-expressing phase and the γ-secretase-affecting phase, respectively. "

Related Drugs and Biologics

1.	Amyloid Precursor Protein Secretases (beta-Secretase)
2.	Antigens
3.	Notch Receptors
4.	Ovalbumin
5.	Cholera Toxin
6.	Allergens
7.	cyclohexyl 2,7,7- trimethyl- 4- (4- nitrophenyl)- 5- oxo- 1,4,5,6,7,8- hexahydroquinoline- 3- carboxylate