HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

D- phenylalanyl- D- phenylalanyl- D- norleucyl- N- (4- pyridinylmethyl)- D-argininamide

Also Known As:

D-argininamide, D-phenylalanyl-D-phenylalanyl-D-norleucyl-N-(4-pyridinylmethyl)-; CR665; FE 200665; FE200665

Networked: 3 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Nerve Tissue Proteins: 2
    - Neuropeptides: 6772
      - Opioid Peptides: 1339
        D-phenylalanyl-D-phenylalanyl-D-norleucyl-N-(4-pyridinylmethyl)- D-argininamide: 3
- Peptides: 82426
  - Neuropeptides: 6772
    - Opioid Peptides: 1339
      - D-phenylalanyl-D-phenylalanyl-D-norleucyl-N-(4-pyridinylmethyl)- D-argininamide: 3

Experts

1.	Arendt-Nielsen, Lars: 2 articles (02/2013 - 09/2009)
2.	Drewes, Asbjørn M: 2 articles (02/2013 - 09/2009)
3.	Kell, Sherron: 2 articles (02/2013 - 09/2009)
4.	Olesen, Anne E: 2 articles (02/2013 - 09/2009)
5.	Staahl, Camilla: 2 articles (02/2013 - 09/2009)
6.	Wong, Gilbert Y: 2 articles (02/2013 - 09/2009)
7.	Kristensen, Kim: 1 article (02/2013)
8.	Brower, Justin O: 1 article (01/2013)
9.	Dix, Thomas A: 1 article (01/2013)
10.	Hughes, Francis M: 1 article (01/2013)

Related Diseases

1.	Pain (Aches) 09/01/2009 - "Compared to placebo, CR665 significantly increased the pain rating threshold to esophageal distension (P < 0.005) but reduced the pain tolerance threshold to skin pinching (P = 0.007). " 01/01/2013 - "In this study we have generated a series of derivatives of CR665 and screened them for oral activity in the acetic acid-induced rat writhing assay for peripheral pain. " 09/01/2009 - "The objectives of this study were: (1) to assess the effects of a peripherally selective tetrapeptide kappa-opioid receptor agonist, CR665, on experimental pain from multi-modal stimulation of skin, muscle, and viscera, and (2) contrast these effects with those of oxycodone (centrally acting opioid). " 09/01/2009 - "Analgesic efficacy of peripheral kappa-opioid receptor agonist CR665 compared to oxycodone in a multi-modal, multi-tissue experimental human pain model: selective effect on visceral pain."
2.	Visceral Pain 09/01/2009 - "CR665 had a selective effect on visceral pain. " 02/01/2013 - "In a randomized, placebo-controlled, double-blind, three-way crossover study, healthy male volunteers were administered CR665 (0.36 mg/kg, intravenous), oxycodone (15 mg, oral) or placebo (intravenous and oral), followed by assessment of visceral pain tolerance thresholds (VPTT) measured as volume of water (mL) in the bag placed on an oesophageal probe. " 09/01/2009 - "Analgesic efficacy of peripheral kappa-opioid receptor agonist CR665 compared to oxycodone in a multi-modal, multi-tissue experimental human pain model: selective effect on visceral pain."
3.	Neuralgia (Stump Neuralgia) 01/01/2013 - "Although not orally available, CR665 given i.v. exhibits high peripheral to CNS selectivity and benefits patients with visceral and neuropathic pain. "

Related Drugs and Biologics

1.	Oxycodone (Oxycontin)
2.	kappa Opioid Receptors (kappa Opioid Receptor)
3.	Analgesics (Analgesic Drugs)
4.	Acetic Acid (Vinegar)
5.	Opioid Analgesics (Opioids)