bovine betaE11 antigen

highly abundant on the surface of mitotic vascular endothelial cells and tumor cells; MW 190-kDa; approximately threefold higher in mitotic versus interphase endothelial cells

Also Known As:

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Herman, I M: 1 article (07/2001)
2.	Papetti, M: 1 article (07/2001)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2001 - "Expression of the betaE11 antigen during mitosis functionally links it to a fundamental aspect of cell proliferation, and its spatial localization on the surface of both proliferating endothelium and tumor cells demonstrates its potential for tumor immunotherapy." 07/01/2001 - "Furthermore, the betaE11 antigen localizes to regions of prostatic intraductal neoplasia in paraffin-embedded sections. " 07/01/2001 - "Treatment of tumor cells with an antibody to the betaE11 antigen inhibits their growth in a dose-dependent manner in vitro with maximal inhibition at an antibody concentration of 1 microg/ml. Different tumor cell lines demonstrate varying sensitivities to anti-betaE11 with the following order of growth inhibition: colon > prostate = glioma > melanoma = fibroblast > breast > liver. "
2.	Melanoma (Melanoma, Malignant) 07/01/2001 - "Treatment of tumor cells with an antibody to the betaE11 antigen inhibits their growth in a dose-dependent manner in vitro with maximal inhibition at an antibody concentration of 1 microg/ml. Different tumor cell lines demonstrate varying sensitivities to anti-betaE11 with the following order of growth inhibition: colon > prostate = glioma > melanoma = fibroblast > breast > liver. "
3.	Glioma (Gliomas) 07/01/2001 - "Treatment of tumor cells with an antibody to the betaE11 antigen inhibits their growth in a dose-dependent manner in vitro with maximal inhibition at an antibody concentration of 1 microg/ml. Different tumor cell lines demonstrate varying sensitivities to anti-betaE11 with the following order of growth inhibition: colon > prostate = glioma > melanoma = fibroblast > breast > liver. "

Related Drugs and Biologics

1.	Paraffin

Related Therapies and Procedures

1.	Immunotherapy