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D2A21

a synthezied peptide; amino acid sequence in first source

Networked: 7 relevant articles (3 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Pore Forming Cytotoxic Proteins
      - Antimicrobial Cationic Peptides: 414
        D2A21: 7
- Peptides: 82426
  - Antimicrobial Peptides: 3727
    - Antimicrobial Cationic Peptides: 414
      - D2A21: 7
  - Antimicrobial Cationic Peptides: 414
    - D2A21: 7

Experts

1.	Chalekson, Charles P: 2 articles (04/2003 - 04/2002)
2.	Jaynes, Jesse: 2 articles (04/2003 - 04/2002)
3.	Neumeister, Michael W: 2 articles (04/2003 - 04/2002)
4.	Hao, Guixia: 1 article (01/2017)
5.	Stover, Ed: 1 article (01/2017)
6.	Zhang, Shujian: 1 article (01/2017)
7.	Bartlett, Jeanine: 1 article (05/2007)
8.	Cummins, James E: 1 article (05/2007)
9.	Dezzutti, Charlene S: 1 article (05/2007)
10.	Flowers, Lisa: 1 article (05/2007)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 05/01/2001 - "These studies were designed to determine the efficacy of one of these novel compounds, D2A21, in the treatment of an animal model of prostate cancer. " 01/01/1998 - "LD50 values recorded for D2A21 and DP1E in cervical, colon, bladder, and lung cancer lines were similar to those obtained in prostate cancer cells. " 01/01/1998 - "As compared with cisplatin, a standard chemotherapeutic drug, the LD50 values recorded for D2A21 were significantly lower (P < 0.04) in prostate-cancer cell lines, suggesting the therapeutic efficacy of Peptidyl MIMs. " 05/01/2001 - "The peptide D2A21 is able to significantly inhibit tumor growth in rat models of prostate cancer. "
2.	Wounds and Injuries (Trauma) 04/01/2002 - "In conclusion, D2A21 demonstrates significant antibacterial activity against Pseudomonas, sterilizing burn eschar and decreasing subeschar bacterial load, allowing for a markedly significant improvement in survival in this infected burn-wound model." 04/01/2002 - "The purpose of this study was to evaluate the effects of D2A21 in an in vivo infected burn-wound model, examining both quantitative cultures of the wound and survival of the animal. " 04/01/2003 - "Treatment of infected wounds with the antimicrobial peptide D2A21." 04/01/2003 - "This study evaluates the use of a particular antimicrobial peptide, D2A21 (Pittsburgh, PA), to combat infection in an acutely infected wound model. "
3.	Burns 04/01/2002 - "In conclusion, D2A21 demonstrates significant antibacterial activity against Pseudomonas, sterilizing burn eschar and decreasing subeschar bacterial load, allowing for a markedly significant improvement in survival in this infected burn-wound model." 04/01/2002 - "The purpose of this study was to evaluate the effects of D2A21 in an in vivo infected burn-wound model, examining both quantitative cultures of the wound and survival of the animal. " 04/01/2002 - "Improvement in burn wound infection and survival with antimicrobial peptide D2A21 (Demegel)."
4.	Wound Infection (Wound Infections) 04/01/2002 - "Improvement in burn wound infection and survival with antimicrobial peptide D2A21 (Demegel)."
5.	Infections 11/01/2000 - "In this study we tested the hypothesis that intravaginal D2A21 would interfere with acquisition of Trichomonas vaginalis infection in a modified mouse model. " 05/01/2007 - "PC-515 and D2A21 prevented HIV-1 infection in 50% or fewer of the explants tested. " 04/01/2003 - "This study evaluates the use of a particular antimicrobial peptide, D2A21 (Pittsburgh, PA), to combat infection in an acutely infected wound model. "

Related Drugs and Biologics

1.	Antimicrobial Peptides
2.	Cisplatin (Platino)
3.	Peptides (Polypeptides)
4.	Anti-Bacterial Agents (Antibiotics)