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L803087

structure in first source

Also Known As:

L-803,087

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - L803087: 2
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - L803087: 2

Experts

1.	Aourz, Najat: 1 article (12/2011)
2.	Clinckers, Ralph: 1 article (12/2011)
3.	De Bundel, Dimitri: 1 article (12/2011)
4.	Michotte, Yvette: 1 article (12/2011)
5.	Portelli, Jeanelle: 1 article (12/2011)
6.	Smolders, Ilse: 1 article (12/2011)
7.	Stragier, Bart: 1 article (12/2011)
8.	Barnes, Steven: 1 article (09/2010)
9.	Brecha, Nicholas C: 1 article (09/2010)
10.	Farrell, Spring R: 1 article (09/2010)

Related Diseases

1.	Ganglion Cysts (Ganglion) 09/01/2010 - "Under voltage clamp, L-803,087 increased outward K(+) currents by 51.1 ± 13.1% at 0 mV and suppressed Ca(2+) channel currents by 32.5 ± 9.4% at -10 mV in whole cell patch-clamped ganglion cells. " 09/01/2010 - "We show that somatostatin receptor subtype 4 (sst(4)) is expressed specifically in rat ganglion cells and that the generation of repetitive action potentials by isolated ganglion cells is reduced in the presence of L-803,087, a selective sst(4) agonist (10 nM). " 09/01/2010 - "In contrast, ganglion cells treated first with nifedipine (NIF, 10 μM), which blocked 46.1 ± 3.5% of the control current at -10 mV, did not undergo any further reduction in I(Ca) in the presence of L-803,087 (-3.5 ± 3.8% vs. NIF), showing that stimulation of sst(4) reduces Ca(2+) influx through L-type Ca(2+) channels. " 09/01/2010 - "The N-type Ca(2+) channel blocker ω-conotoxin GVIA (CTX, 1 μM) reduced L-type Ca(2+) current (I(Ca)) in ganglion cells by 43.5 ± 7.2% at -10 mV, after which addition of L-803,087 further reduced I(Ca) by 28.0 ± 16.0% . "
2.	Seizures (Absence Seizure) 12/01/2011 - "Using microdialysis and telemetry-based electroencephalographic recordings we show that intrahippocampal administration of the sst(2) agonist L-779,976 (500 nM), the sst(3) agonist L-796,778 (100 nM) or the sst(4) agonist L-803,087 (100 nM) protects rats against focal pilocarpine-induced seizures. "

Related Drugs and Biologics

1.	Conotoxins (Conotoxin)
2.	Somatostatin Receptors (Somatostatin Receptor)
3.	Pilocarpine (Ocusert)
4.	Nifedipine (Adalat)
5.	Dihydrotachysterol (AT 10)
6.	L796778
7.	L 779976