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ratjadone

structure in first source

Also Known As:

(+)-ratjadone; ratjadone A

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Pyrones: 35
      - ratjadone: 3

Experts

1.	Diez, Juana: 1 article (01/2014)
2.	Fleta-Soriano, Eric: 1 article (01/2014)
3.	Frank, Ronald: 1 article (01/2014)
4.	Gerth, Klaus: 1 article (01/2014)
5.	Hinkelmann, Bettina: 1 article (01/2014)
6.	Martinez, Javier P: 1 article (01/2014)
7.	Meyerhans, Andreas: 1 article (01/2014)
8.	Sasse, Florenz: 1 article (01/2014)
9.	Washausen, Peter: 1 article (01/2014)
10.	Boucke, Karin: 1 article (06/2005)

Related Diseases

1.	HIV Infections (HIV Infection) 01/29/2014 - "Ratjadone A inhibits HIV infection in vitro in a dose-dependent manner with EC₅₀ values at the nanomolar range. " 01/29/2014 - "The myxobacterial metabolite ratjadone A inhibits HIV infection by blocking the Rev/CRM1-mediated nuclear export pathway."
2.	Neoplasms (Cancer) 08/01/2003 - "In previous screening tests, ratjadone revealed a growth inhibitory effect against bacteria, yeast and human cancer cells. "
3.	Infections 01/29/2014 - "The inhibitory effect of ratjadone A occurs around 12 hours post-infection and is specific for the Rev/CRM1-mediated nuclear export pathway. "
4.	Adenoviridae Infections (Adenovirus Infections) 06/01/2005 - "Two distinct inhibitors of the nuclear export factor CRM1, leptomycin B (LMB) and ratjadone A (RJA) or CRM1-siRNAs blocked adenovirus infection, arrested cytoplasmic transport of viral particles at the microtubule-organizing center or in the cytoplasm and prevented capsid disassembly and nuclear import of the viral genome. "

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