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prostatic acid phosphatase

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Also Known As:

ACP-3 protein, human; ACP3 protein, human; ACPP protein, human; Acpp protein, mouse; Acpp protein, rat; Acpp11 protein, rat; acid phosphatase, prostate, human; acid phosphatase, prostate, mouse; acid phosphatase, prostate, rat; prostatic-specific acid phosphatase

Networked: 698 relevant articles (18 outcomes, 57 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Hydrolases: 639
    - Esterases: 217
      - Phosphoric Monoester Hydrolases: 1062
        Protein Tyrosine Phosphatases: 965
        prostatic acid phosphatase: 698

Experts

1.	McNeel, Douglas G: 8 articles (07/2014 - 12/2005)
2.	Small, Eric J: 7 articles (08/2015 - 10/2003)
3.	Lin, Ming-Fong: 7 articles (01/2015 - 02/2003)
4.	Johnson, Laura E: 6 articles (07/2014 - 01/2006)
5.	Lin, Fen-Fen: 5 articles (01/2015 - 02/2003)
6.	Lin, M F: 5 articles (11/2001 - 01/2000)
7.	Vihko, Pirkko: 4 articles (01/2014 - 10/2008)
8.	Kirchhoff, Frank: 4 articles (01/2012 - 07/2009)
9.	Fong, Lawrence: 4 articles (05/2007 - 10/2003)
10.	Lee, M S: 4 articles (11/2001 - 01/2000)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 02/01/1993 - "Previously, prostatic acid phosphatase (PAP) was used to help diagnose and monitor the efficacy of therapy for prostate cancer. " 07/01/1983 - "We compared a commercial radioimmunoassay kit with an enzymatic assay for prostatic acid phosphatase in monitoring the progression or remission of disease in 27 patients with prostatic cancer. " 08/01/1981 - "[Improved diagnostic evaluation of prostatic neoplasms using radioimmunoassay for prostatic acid phosphatase]." 07/01/2002 - "Another study examined this issue by studying prostatic acid phosphatase (PAP) protein-loaded mature DCs injected intravenously, intradermally, and intralymphatically in prostate cancer patients [45]. " 01/01/1992 - "In this study twenty male urethral specimens were evaluated for PSA and prostatic acid phosphatase (PAP) from patients without evidence of prostatic cancer. "
2.	Carcinoma (Carcinomatosis) 02/15/2003 - "The objective of this study was to define the long-term prognostic significance of prostatic acid phosphatase (PAP) levels in patients with higher risk, early-stage prostate carcinoma. " 06/01/2002 - "The level of prostatic acid phosphatase in serum is an established marker for prostate carcinoma. " 11/01/1999 - "Prognostic role of serum prostatic acid phosphatase for 103Pd-based radiation for prostatic carcinoma." 04/28/1995 - "The expression of prostatic acid phosphatase is transcriptionally regulated in human prostate carcinoma cells." 02/01/1995 - "An open biopsy revealed undifferentiated tissue that stained strongly positive for prostatic-specific acid phosphatase, confirming the diagnosis of metastatic prostate carcinoma."
3.	Neoplasms (Cancer) 06/01/1983 - "No major adverse effects were noted with this treatment modality, and all patients were symptomatically improved and demonstrated a decrease or stabilization in tumor activity as measured by prostatic computerized tomography or ultrasound scan, prostatic acid phosphatase and bone scan. " 04/01/1999 - "On the basis of this blinded study, RT-PCR for PSA-expressing cells in 85 patients before RP is not related to clinical stage, age, race, grade, Gleason sum, serum PSA or prostatic acid phosphatase, tumor volume, or tumor multifocality. " 09/01/2015 - "Our results document the suppression of subcutaneous tumor growth in animals immunized with AAV6-S663V+T492V vectors expressing prostatic acid phosphatase (PAP) for approximately 4 weeks in comparison with 1 week and 2 weeks for the negative controls, AAV6-EGFP, and AAV6-WT-PAP treated mice, respectively. " 08/01/2014 - "Cellular prostatic acid phosphatase, a PTEN-functional homologue in prostate epithelia, functions as a prostate-specific tumor suppressor." 07/01/2012 - "Immunohistochemical staining with PSA and Prostatic Acid Phosphatase (PAP) can help in establishing prostatic nature of the neoplasm. "
4.	Pain (Aches) 07/01/1984 - "Pain was improved and serum prostatic acid phosphatase levels had decreased significantly, and by 1 month prostatic acid phosphatase had reached the normal range. " 05/01/1999 - "A 62-year-old man was referred to our department because of abnormal prostatic acid phosphatase and pain in his right upper arm. " 01/01/1993 - "The combination regimen produced a more rapid normalisation of prostatic acid phosphatase levels and a prompt relief of bone pain. " 11/01/2013 - "Prostatic acid phosphatase (PAP) has been considered as a diagnostic marker for prostate cancer and its transmembrane isoform has been reported to play an antinociceptive effect in neuropathic and inflammatory pain. " 11/01/2013 - "Antinociceptive effect of prostatic acid phosphatase in a rat model of cancer-induced bone pain."
5.	Adenocarcinoma 05/01/1985 - "Furthermore, under electron microscopic study, prostatic specific acid phosphatase granules were uniformly and intensely condensed in intracytoplasmic vacuoles in well differentiated adenocarcinomas, whereas in moderately or poorly differentiated adenocarcinomas 2 types of staining were observed. " 03/01/1980 - "Results of such a study show an increased diagnostic sensitivity of the radioimmunoassay in all stages, but in 14% of Stage IV adenocarcinomas there was no increase in prostatic acid phosphatase above the ranges ordinarily expected for all methods. " 01/01/2013 - "Transmembrane prostatic acid phosphatase (TMPAP) interacts with snapin and deficient mice develop prostate adenocarcinoma." 07/01/1987 - "The usefulness of clinical stage, serum prostatic acid phosphatase and preoperative Gleason grade in predicting final pathological stage in patients with adenocarcinoma of the prostate remains controversial. " 07/01/1987 - "Correlation of clinical stage, serum prostatic acid phosphatase and preoperative Gleason grade with final pathological stage in 275 patients with clinically localized adenocarcinoma of the prostate."

Related Drugs and Biologics

1.	Prostate-Specific Antigen (Semenogelase)
2.	Antigens
3.	sipuleucel-T (APC8015)
4.	Biological Markers (Surrogate Marker)
5.	Alkaline Phosphatase
6.	Biological Tumor Markers (Tumor Markers)
7.	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)
8.	DNA (Deoxyribonucleic Acid)
9.	A-Form DNA (A-DNA)
10.	Heat-Shock Proteins (Heat-Shock Protein)

Related Therapies and Procedures

1.	Immunotherapy
2.	Aftercare (After-Treatment)
3.	Prostatectomy (Retropubic Prostatectomy)
4.	Castration
5.	Radiotherapy