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MLK-like mitogen-activated protein triple kinase

increased by activation of the ERK/MAPK pathway: MLTKalpha and beta are alternatively spliced forms; GenBank AB049731- AB049734

Also Known As:

MLTK; MLTKalpha; MLTKbeta

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9677
        Protein Serine-Threonine Kinases: 3588
        MAP Kinase Kinase Kinases: 388
        MLK-like mitogen-activated protein triple kinase: 1
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein Serine-Threonine Kinases: 3588
      - MAP Kinase Kinase Kinases: 388
        MLK-like mitogen-activated protein triple kinase: 1

Experts

1.	Bode, Ann M: 1 article (06/2004)
2.	Cho, Yong-Yeon: 1 article (06/2004)
3.	Choi, Bu Young: 1 article (06/2004)
4.	Choi, Hong Seok: 1 article (06/2004)
5.	Dong, Zigang: 1 article (06/2004)
6.	Mizuno, Hideya: 1 article (06/2004)

Related Diseases

1.	Carcinogenesis 06/01/2004 - "Here, we demonstrate that MLK-like mitogen-activated protein triple kinase (MLTK)-alpha, a member of the MLK family, induced neoplastic cell transformation and tumorigenesis in athymic nude mice. "
2.	Neoplasms (Cancer) 06/01/2004 - "These results are the first to indicate that MLTK-alpha plays a key role in neoplastic cell transformation and cancer development." 06/01/2004 - "into athymic nude mice, whereas almost no tumor formation was observed in mice that received injections of mock or siRNA-MLTK-alpha stably transfected cells. "
3.	Fibrosarcoma 06/01/2004 - "Very importantly, MLTK-alpha-overexpressing cells formed fibrosarcomas when injected s.c. "
4.	Neoplastic Cell Transformation 06/01/2004 - "These results are the first to indicate that MLTK-alpha plays a key role in neoplastic cell transformation and cancer development." 06/01/2004 - "Here, we demonstrate that MLK-like mitogen-activated protein triple kinase (MLTK)-alpha, a member of the MLK family, induced neoplastic cell transformation and tumorigenesis in athymic nude mice. "

Related Drugs and Biologics

1.	MLK-like mitogen-activated protein triple kinase
2.	Small Interfering RNA (siRNA)

Related Therapies and Procedures

1.	Injections