RELT

RELT - Receptor Expressed in Lymphoid Tissues; a member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-kappaB; GenBank AI071067 (rat), AB046039 (macaque), AF319553 (human)

Networked: 32 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Adam, René: 3 articles (10/2021 - 11/2018)
2.	Cherqui, Daniel: 3 articles (10/2021 - 11/2018)
3.	Polak, Wojciech G: 2 articles (10/2021 - 01/2020)
4.	Porte, Robert J: 2 articles (10/2021 - 01/2020)
5.	Bartlett, John D: 2 articles (10/2019 - 01/2019)
6.	Ikeda, Atsushi: 2 articles (10/2019 - 01/2019)
7.	Castaing, Denis: 2 articles (11/2018 - 05/2016)
8.	Fondevila, Constantino: 2 articles (11/2018 - 07/2014)
9.	Fuster, Josep: 2 articles (11/2018 - 07/2014)
10.	García-Valdecasas, Juan Carlos: 2 articles (11/2018 - 07/2014)

Related Diseases

1.	Infections 10/01/2023 - "Higher 5-year mortality in ReLT is due to CVD and infections. " 10/01/2023 - "ReLT is associated with higher rates of 5-year mortality, overall morbidity, CVD morbidity, infection, and graft failure. " 10/01/2023 - "Compared to first LT, ReLT patients had a significant increase in overall 5-year mortality (p < 0.001), 5-year mortality due to CVD complications (p < 0.001), infection (p = 0.009), but not graft failure (p = 0.3543). " 01/01/2019 - "Phylogenetic analyses showed the existence of selective pressure on RELT gene outside of tooth development, indicating that the human condition may be syndromic, which possibly explains the history of small stature and severe childhood infections in two of the probands. " 07/01/2014 - "Early severe HCV infection rate was similar in both groups, but it affected prognosis in ReLT more markedly than in LT (three-yr graft survival: 0% vs. 66.7%, p = 0.003). "
2.	Hemorrhage 10/01/2023 - "Morbidity including cardiovascular (CVD) complications (OR 1.32, 95%CI 1.08-1.60), graft failure (OR 2.18, 95%CI 1.84-2.57), infection (OR 2.13, 95%CI 1.82-2.50), and hemorrhage (OR 2.67, 95%CI 2.00-3.61) were significantly greater in ReLT recipients. " 10/01/2001 - "9 children developed symptomatic PPH (hemorrhage in 8, ascites in 1), associated to lymphoproliferative post-LT disease in 2, and to anastomotic biliary stricture in 1. The age at first LT (children under 1 year old), weight (below 10 kg), and need of retransplantation (reLT) were in the univariant analysis the associated variables with increased risk of PPH. "
3.	Neoplasms (Cancer) 12/01/2023 - "RELT, a SigIQGAP3NW component gene, was associated with elevations of multiple immune checkpoints and the infiltration of Treg and myeloid-derived suppressor cells in PC and across cancer types. " 01/01/2021 - "An inhibitor of NF-κB reversed the RELT-induced malignancy in the ESCC cells. " 10/01/2018 - "Using RELT knockout (RELT-/- ) mice, we demonstrate that RELT deficiency selectively promotes the homeostatic proliferation of CD4+ T cells but not CD8+ T cells, and enhances anti-tumor CD8+ T-cell responses. " 12/01/2023 - "In multiple cancers, IQGAP3 robustly correlates with PLK1 and TOP2A expression, and SigIQGAP3NW and/or RELT effectively predict mortality risk and/or resistance to ICB therapy. " 01/01/2021 - "However, little is known about the function of the Receptor Expressed in Lymphoid Tissues (RELT) in cancers, which is a member of the TNFR family, especially in the esophageal squamous cell carcinoma (ESCC). "
4.	Amelogenesis Imperfecta 11/01/2023 - "Recently, five biallelic disease-causing variants in the RELT gene were identified in 7 families with autosomal recessive amelogenesis imperfecta (ARAI). " 11/01/2023 - "Oro-dental phenotyping and report of three families with RELT-associated amelogenesis imperfecta." 01/01/2020 - "New missense variants in RELT causing hypomineralised amelogenesis imperfecta." 10/01/2019 - "This striking result is significant because RELT mutations cause amelogenesis imperfecta (AI) and this directly links ADAM10 to an important role in enamel development." 01/01/2019 - "Mutations in RELT cause autosomal recessive amelogenesis imperfecta."
5.	End Stage Liver Disease 10/01/2021 - "The final model included seven predictors of graft survival: recipient age, model for end-stage liver disease score, indication for reLT, recipient hospitalization, time between primary liver transplantation and reLT, donor age, and cold ischemia time. " 09/01/2011 - "Eight risk factors predictive for GF after ReLT included recipient age greater than 55 years, Model for End-Stage Liver Disease score greater than 27, history of prior OLT greater than 1, pre-ReLT requirement for mechanical ventilation, serum albumin less than 2.5 g/dL, donor age greater than 45 years, intraoperative requirement of packed red blood cell transfusion greater than 30 units, and performance of ReLT between 15 and 180 days from the prior OLT. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	dicarboxydine (DCD)
3.	Cyclin B1
4.	Insulin-Like Growth Factor Binding Protein 2
5.	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)
6.	Cytokines
7.	Urea (Carbamide)
8.	Transcription Factors (Transcription Factor)
9.	Serum Albumin
10.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Liver Transplantation
2.	Therapeutics
3.	Erythrocyte Transfusion
4.	Stents
5.	Transplantation