fosamprenavir (Lexiva)

a prodrug of the protease inhibitor amprenavir

Also Known As:

Lexiva; (3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-1-(phenylmethyl)-2-(phosphonooxy)propyl)carbamic acid C-(tetrahydro-3-furanyl) ester; GW 433908; GW 433908A; GW 433908G; GW 908; GW-433908; GW-433908A; GW-433908G; GW-908; GW433908; GW433908G; Telzir; VX 175; VX-175; fos-amprenavir; fosamprenavir calcium; fosamprenavir sodium

Networked: 45 relevant articles (2 outcomes, 6 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	DeJesus, Edwin: 3 articles (03/2008 - 05/2006)
2.	Yeo, Jane: 3 articles (08/2006 - 01/2004)
3.	Nasta, Paola: 2 articles (01/2016 - 03/2009)
4.	Fragola, V: 2 articles (12/2014 - 12/2012)
5.	Weimer, L E: 2 articles (12/2014 - 12/2012)
6.	Manfredi, R: 2 articles (12/2012 - 08/2008)
7.	Moral, M A: 2 articles (11/2009 - 05/2009)
8.	Tomillero, A: 2 articles (11/2009 - 05/2009)
9.	Burty, Christine: 2 articles (11/2008 - 01/2007)
10.	Pavel, Simona: 2 articles (11/2008 - 01/2007)

Related Diseases

1.	Infections 02/01/2007 - "Once-daily (QD) fosamprenavir (FPV) at 1,400 mg boosted with low-dose ritonavir (RTV) at 200 mg is effective when it is used in combination regimens for the initial treatment of human immunodeficiency virus infection. " 06/01/2007 - "Fosamprenavir is a protease inhibitor (PI) approved for the treatment of HIV-1 infection. " 07/01/2006 - "Fosamprenavir is a protease inhibitor (PI) prodrug used for the treatment of HIV-1 infection. " 04/01/2006 - "Effects of esomeprazole on the pharmacokinetics of atazanavir and fosamprenavir in a patient with human immunodeficiency virus infection." 05/01/2006 - "Long-term (120-Week) antiviral efficacy and tolerability of fosamprenavir/ritonavir once daily in therapy-naive patients with HIV-1 infection: an uncontrolled, open-label, single-arm follow-on study."
2.	Diarrhea 02/01/2009 - "In drug-naïve subjects, regimens based on ATV/r have shown non-inferiority compared to lopinavir (LPV)/r (CASTLE study) or fosamprenavir/r (ALERT trial), generally with improved tolerance (less diarrhea and dyslipidemia). " 01/01/2009 - "Overall, lopinavir/ritonavir and fosamprenavir/ritonavir tend to show the highest rates of drug-related grade 2-4 diarrhea, compared with atazanavir/ritonavir, darunavir/ritonavir, or saquinavir/ritonavir. "
3.	Dyslipidemias (Dyslipidemia) 02/01/2009 - "In drug-naïve subjects, regimens based on ATV/r have shown non-inferiority compared to lopinavir (LPV)/r (CASTLE study) or fosamprenavir/r (ALERT trial), generally with improved tolerance (less diarrhea and dyslipidemia). "
4.	HIV Infections (HIV Infection) 08/01/2002 - "The possibility of a lower pill burden offered by GW433908 may be of clinical benefit in the treatment of HIV infection." 01/01/2004 - "In conclusion, fosamprenavir appears to be a promising agent for the treatment of antiretroviral therapy-naive patients with HIV infection." 01/01/2004 - "Fosamprenavir: a review of its use in the management of antiretroviral therapy-naive patients with HIV infection." 06/01/2007 - "Fosamprenavir calcium plus ritonavir for HIV infection." 12/01/2008 - "Once-daily fosamprenavir with ritonavir in the treatment of HIV infection in therapy-naïve patients."
5.	Coinfection 05/01/2012 - "Hepatic safety profile of fosamprenavir-containing regimens in HIV-1-infected patients with or without hepatitis B or C coinfection." 01/01/2016 - "Fosamprenavir/ritonavir in patients with viral hepatitis coinfection: an observational multicohort study." 01/01/2016 - "Safety and tolerability evaluation of adapted dose regimens containing fosamprenavir/ritonavir (FPV/r) in HIV-infected subjects with viral hepatitis co-infection. " 09/01/2008 - "To appraise the incidence of liver toxicity in a population of patients receiving fosamprenavir/ritonavir (FPV/r) with a high frequency of viral hepatitis co-infection. "

Related Drugs and Biologics

1.	Ritonavir (Norvir)
2.	Lopinavir
3.	Protease Inhibitors (Protease Inhibitor)
4.	lamivudine drug combination abacavir
5.	amprenavir (Agenerase)
6.	Lamivudine (Epivir)
7.	Darunavir (Prezista)
8.	Prodrugs
9.	abacavir (Ziagen)
10.	Nelfinavir (Viracept)

Related Therapies and Procedures

1.	Therapeutics
2.	Pain Management
3.	Liver Transplantation
4.	Stents
5.	Highly Active Antiretroviral Therapy (HAART)