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benzyloxycarbonyl- valyl- alanyl- (methyl)aspartic acid fluoromethyl ketone

a pan-caspase inhibitor

Also Known As:

Z-Val-Ala-Asp(OMe)-CH2F

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Amino Acid Chloromethyl Ketones
    - benzyloxycarbonyl-valyl-alanyl-(methyl)aspartic acid fluoromethyl ketone: 3

Experts

1.	Der Sarkissian, Shant: 1 article (04/2003)
2.	Hamet, Pavel: 1 article (04/2003)
3.	Marchand, Eve-Lyne: 1 article (04/2003)
4.	deBlois, Denis: 1 article (04/2003)
5.	Aoyama, T: 1 article (10/2001)
6.	Arai, M: 1 article (10/2001)
7.	Fujiwara, H: 1 article (10/2001)
8.	Fujiwara, T: 1 article (10/2001)
9.	Hashimoto, K: 1 article (10/2001)
10.	Kariya, T: 1 article (10/2001)

Related Diseases

1.	Vascular Remodeling 04/18/2003 - "We postulated that SMC death and vascular remodeling in this model may be attenuated by z-Val-Ala-Asp(OMe)-CH2F (z-VAD-fmk), a tripeptide inhibitor of caspase enzymes mediating apoptosis. "
2.	Coronary Occlusion 10/01/2001 - "A vehicle (dimethylsulfoxide, control group, n=8) or Z-Val-Ala-Asp(Ome)-CH2F (ZVAD-fmk, a caspase inhibitor, ZVAD group, 0.8 mg/kg iv at 20 min before coronary occlusion and 0.8 mg/kg at 90 min after reperfusion, n=8) or 3,4-dichloroisocoumarin (DCI, a serine protease inhibitor, 2 mg/kg iv at 20 min before coronary occlusion, DCI group, n=8) was administered. "
3.	Myocardial Reperfusion Injury 01/27/1998 - "Z-Val-Ala-Asp(OMe)-CH2F (ZVAD-fmk), a tripeptide inhibitor of the caspase interleukin-1beta-converting enzyme family of cysteine proteases, may reduce myocardial reperfusion injury in vivo by attenuating cardiomyocyte apoptosis within the ischemic area at risk. "

Related Drugs and Biologics

1.	Caspases
2.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone
3.	Enzymes
4.	Cysteine Proteases (Cysteine Protease)
5.	Serine Proteinase Inhibitors (Serine Protease Inhibitors)
6.	Dimethyl Sulfoxide (DMSO)
7.	3,4-dichloroisocoumarin