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KN 92

KN 93 isomer; a calcium/calmodulin-dependent kinase II inhibitor;

Also Known As:

(2-(N-(4-Methoxybenzenesulfonyl))amino-N-(4-chlorocinnamyl)-N-methylbenzylamine, phosphate); KN-92

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Liu, Nian: 2 articles (01/2011 - 01/2007)
2.	Bapat, Aneesh: 1 article (10/2015)
3.	Cao, Hong: 1 article (10/2015)
4.	Eskandari, Anahita: 1 article (10/2015)
5.	Karagueuzian, Hrayr S: 1 article (10/2015)
6.	Ko, Christopher Y: 1 article (10/2015)
7.	Nguyen, Thao: 1 article (10/2015)
8.	Nivala, Michael: 1 article (10/2015)
9.	Pezhouman, Arash: 1 article (10/2015)
10.	Qu, Zhilin: 1 article (10/2015)

Related Diseases

1.	Ventricular Tachycardia 01/01/2011 - "CaMKII inhibition with KN-93 completely prevented catecholamine-induced sustained ventricular tachyarrhythmia in RyR2(R4496C+/-) mice, while the inactive congener KN-92 had no effect. " 10/20/2015 - "Pretreatment with the Ca-calmodulin kinase II (CaMKII) inhibitor KN-93, but not its inactive analogue KN-92, abolished EADs and hypokalemia-induced ventricular tachycardia/fibrillation, as did the selective late Na current (INa) blocker GS-967. "
2.	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 01/01/2007 - "Left ventricular hypertrophy was detected in LVH group by echocardiography and not affected by KN-92 and KN-93. "
3.	Neoplasms (Cancer) 07/01/2015 - "On the other hand, KN-93 and KN-92 did not markedly inhibit apoptosis induced by anti-cancer agents such as etoposide, actinomycin D, ABT-737, or TW-37, indicating that the mechanism of inhibition is specific to apoptosis induced by NAD depletion. "
4.	Necrosis 06/01/2010 - "CaMKII-inhibition (KN-93), significantly decreased phospholamban phosphorylation, infarct area, lactate dehydrogenase release (LDH) (necrosis), TUNEL positive nuclei, caspase-3 activity, Bax/Bcl-2 ratio and Ca(2+)-induced mitochondrial swelling (apoptosis), and increased contractile recovery when compared with non-treated IR hearts or IR hearts pretreated with the inactive analog, KN-92. "
5.	Infarction (Infarctions) 06/01/2010 - "CaMKII-inhibition (KN-93), significantly decreased phospholamban phosphorylation, infarct area, lactate dehydrogenase release (LDH) (necrosis), TUNEL positive nuclei, caspase-3 activity, Bax/Bcl-2 ratio and Ca(2+)-induced mitochondrial swelling (apoptosis), and increased contractile recovery when compared with non-treated IR hearts or IR hearts pretreated with the inactive analog, KN-92. "

Related Drugs and Biologics

1.	KN 93
2.	Calcium-Calmodulin-Dependent Protein Kinase Type 2
3.	Caspase 3 (Caspase-3)
4.	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)
5.	Calcium-Calmodulin-Dependent Protein Kinases
6.	NAD (NADH)
7.	L-Lactate Dehydrogenase (Lactate Dehydrogenase)
8.	Etoposide (VP 16)
9.	Dactinomycin (Actinomycin)
10.	Catecholamines