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spiramine T

from Spiraea japonica; structure in first source

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 4 or More Rings Heterocyclic Compounds
    - spiramine T: 2

Experts

1.	Chen, Zhi-He: 1 article (07/2002)
2.	Hao, Xiao-Jiang: 1 article (07/2002)
3.	Li, Ling: 1 article (07/2002)
4.	Shen, Yue-Mao: 1 article (07/2002)
5.	Wang, Bin-Gui: 1 article (07/2002)
6.	Wu, Wan-Ling: 1 article (07/2002)
7.	Yang, Xiao-Sheng: 1 article (07/2002)
8.	Chen, Z: 1 article (03/2001)
9.	Hao, X: 1 article (03/2001)
10.	Li, L: 1 article (03/2001)

Related Diseases

1.	Reperfusion Injury 03/01/2001 - "These results suggested that spiramine T exhibited protective effects on cerebral ischemia-reperfusion injury in gerbils, and its mechanism might be related to reducing calcium accumulation and lipid peroxidation. " 07/19/2002 - "Spiramine T, an atisine-type diterpene alkaloid isolated from the Chinese herbal medicine Spiraea japonica var. acuta (Rosaceae), was shown to have neuroprotective effects on cerebral ischemia-reperfusion injury. " 03/01/2001 - "The neuroprotective effects of spiramine T, an atisine-type diterpenoid alkaloid isolated from the Chinese herbal medicine Spiraea japonica var. acuta (Rosaceaee), on cerebral ischemia-reperfusion injury produced by 10-min bilateral occlusion of the common carotid arteries followed by 5-day reperfusion in gerbils were investigated. "
2.	Brain Ischemia (Cerebral Ischemia) 03/01/2001 - "These results suggested that spiramine T exhibited protective effects on cerebral ischemia-reperfusion injury in gerbils, and its mechanism might be related to reducing calcium accumulation and lipid peroxidation. " 07/19/2002 - "Effects of spiramine T on antioxidant enzymatic activities and nitric oxide production in cerebral ischemia-reperfusion gerbils." 07/19/2002 - "Spiramine T, an atisine-type diterpene alkaloid isolated from the Chinese herbal medicine Spiraea japonica var. acuta (Rosaceae), was shown to have neuroprotective effects on cerebral ischemia-reperfusion injury. " 03/01/2001 - "The neuroprotective effects of spiramine T, an atisine-type diterpenoid alkaloid isolated from the Chinese herbal medicine Spiraea japonica var. acuta (Rosaceaee), on cerebral ischemia-reperfusion injury produced by 10-min bilateral occlusion of the common carotid arteries followed by 5-day reperfusion in gerbils were investigated. "
3.	Ischemia 07/19/2002 - "In this study, the effects of spiramine T on antioxidant enzymes and nitric oxide production were evaluated in gerbils subjected to global forebrain ischemia (10 min) and reperfusion (5 days). " 07/19/2002 - "Spiramine T (1.0 and 2.0 mg kg(-1) i.p.) markedly reduced the content of lipid peroxide (LPO), increased the glutathione peroxidase (GSH-PX) activity, and inhibited the increase of nitric oxidase (NOS) activity and nitric oxide production in the cortex during ischemia-reperfusion in gerbils. "
4.	Stroke (Strokes) 03/01/2001 - "Intravenous spiramine T (0.38, 0.75, and 1.5 mg.kg-1) markedly reduced the stroke index, enhanced the recovery of EEG amplitude during reperfusion and decreased the concentrations of cortex calcium and LPO in a dose-dependent manner. "

Related Drugs and Biologics

1.	Calcium
2.	Nitric Oxide (Nitrogen Monoxide)
3.	Enzymes
4.	Antioxidants
5.	Neuroprotective Agents
6.	Oxidoreductases (Dehydrogenase)
7.	Lipid Peroxides
8.	Glutathione Peroxidase
9.	Diterpenes
10.	Alkaloids