telomerase RNA (bTR)

04/20/2008 - "[Study on growth inhibition of implanted tumor in nude mice by antisense oligodeoxynucleotide targeting telomerase RNA.]."
08/01/2005 - "In addition, to undertake a linkage study between the BTR database and that of the WA Cancer Registry (WACR) for the years 1980-1996 to determine if the BTR records could be regarded as population-based and valid for determining incidence rates in WA. "
11/01/2015 - "No correlation was observed between TERT and TERC expression level and tumor size in any tumor type. "
08/28/2015 - "These results indicate that the influence of dyskerin expression on tumor clinical outcome is linked to its role on the maintenance of high levels of TERC. "
08/28/2015 - "Similarly, the association between dyskerin expression and survival was found in cases not bearing TERC gene amplification (P = 0.009) and was not observed in TERC amplified tumors (P = 0.584). "

01/01/2015 - "The new metabolism-related index, GA/HbA1c/BTR value, is shown to relate to the degree of liver fibrosis in HCV-positive patients. "
05/01/2013 - "A decreased BTR value was found to be associated with the progression of liver fibrosis and severity of varices."
06/01/1992 - "These diagnostic results showed that BTR is a superior indicator in discriminating between liver cirrhosis and chronic hepatitis."
05/01/1999 - "BTR in chronic hepatitis C patients seems to be reflected by the extent of liver fibrosis, and, in the responder group, it can be improved, together with liver fibrosis, by interferon-alpha treatment."
04/01/2012 - "Mutations in TERT, the catalytic component, and TERC, the RNA template, can behave as risk factors for the development of bone marrow failure, pulmonary fibrosis, and hepatic cirrhosis. "

05/01/2013 - "The mean values of the BTR decreased with the progression of the fibrosis (METAVIR score: F0-1: 6.40 ± 1.19; F2: 5.85 ± 1.33; F3: 5.24 ± 0.97, F4: 4.78 ± 1.14). "
09/07/2012 - "This review discusses data regarding the effect of early administration of BCAA granules based on the ratio of BCAA to BTR on prognosis in patients with cirrhosis."
05/07/2012 - "BTR correlates with various liver function examinations, including markers of hepatic fibrosis, hepatic blood flow and hepatocyte function, and can thus be considered as reflecting the degree of hepatic impairment. "
05/01/2011 - "In all, 134 patients with cirrhosis of common etiologies treated at the Liver Research Institute, University of Arizona, between May 2008 and July 2009, and 528 healthy subjects were screened for variation in the TERT and TERC genes by direct sequencing; an additional 1,472 controls were examined for the most common genetic variation observed in patients. "
05/01/1999 - "There was a good correlation between BTR and staging (fibrosis) scores both before and after treatment. "

05/01/1992 - "Treatment of brain metastases with WBRT, BTR, C/T, or in combinations also improved the quality of life. "
06/01/2015 - "Multivariate regression analysis showed that lymph node metastasis and high TERC expression were independent prognostic factors of reduced overall survival (OS) for patients with GEP-NETs. "
02/01/2012 - "Patients who have solitary BM with the absence of extracranial metastases may be indicated for SRS monotherapy given the lower risk of BTR compared with those having multiple BMs or extracranial metastases."
10/01/2011 - "In an RCT between SRS-alone and SRS + WBRT conducted in Japan, we found that patients who had a single BM and no extracranial metastases had a low risk of developing BTR after initial brain management (low-risk group) compared with those who had 2 or more BM and extracranial metastases (high-risk group). "
02/01/2002 - "Forty-seven percent of BTR (8/17) recurred at the site of original metastasis; 35% (6/17) recurred at both original [corrected] and distant sites in the brain, and 18% (3/17) recurred at distant only [corrected] brain sites. "

05/01/1999 - "We used this method to investigate the diagnostic implications of serum BTR in patients with chronic hepatitis C treated with interferon-alpha. "
05/01/1999 - "BTR in chronic hepatitis C patients seems to be reflected by the extent of liver fibrosis, and, in the responder group, it can be improved, together with liver fibrosis, by interferon-alpha treatment."
05/01/1999 - "Improvement of molar ratio of branched-chain amino acids to tyrosine (BTR) associated with liver fibrosis in chronic hepatitis C patients treated with interferon-alpha."