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A 105972

structure in first source

Also Known As:

A-105972

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Oxazoles: 89
      - Oxadiazoles: 146
        A 105972: 1

Experts

1.	Alder, J D: 1 article (02/2001)
2.	Alder, L: 1 article (02/2001)
3.	Burns, D J: 1 article (02/2001)
4.	Chiou, W J: 1 article (02/2001)
5.	Credo, B: 1 article (02/2001)
6.	Dayton, B D: 1 article (02/2001)
7.	Ewing, P J: 1 article (02/2001)
8.	Han, E K: 1 article (02/2001)
9.	Tahir, S K: 1 article (02/2001)
10.	Wu-Wong, J R: 1 article (02/2001)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 02/15/2001 - "A-105972 is a small molecule that inhibits the growth of breast, central nervous system, colon, liver, lung, and prostate cancer cell lines, including multidrug-resistant cells. "
2.	Neoplasms (Cancer) 02/15/2001 - "A-105972 and its analogues may be useful for treating cell proliferative disorders such as cancer." 02/15/2001 - "These results suggest that A-105972 is a small molecule that interacts with microtubules, arrests cells in G2-M phases, and induces apoptosis in both multidrug resistance-negative and multidrug resistance-positive cancer cells. " 02/15/2001 - "Tumor cells treated with A-105972 were observed to contain abnormal microtubule arrangement and apoptotic bodies. "
3.	Experimental Melanoma 02/15/2001 - "A-105972 treatment increased the life span of mice inoculated with B16 melanoma, P388 leukemia, and Adriamycin-resistant P388. "
4.	Leukemia P388 02/15/2001 - "A-105972 treatment increased the life span of mice inoculated with B16 melanoma, P388 leukemia, and Adriamycin-resistant P388. "

Related Drugs and Biologics

1.	Doxorubicin (Adriamycin)