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1- (3- (aminomethyl)phenyl)- N- (3- fluoro- 2'- (methylsulfonyl)(1,1'- biphenyl)- 4- yl)- 3- (trifluoromethyl)- 1H- pyrazole- 5- carboxamide

DPC423 is the HCl salt; structure in first source

Also Known As:

DPC 423; DPC-423; DPC423

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - 1-(3-(aminomethyl)phenyl)-N-(3-fluoro-2'-(methylsulfonyl)(1,1'-biphenyl)-4-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide: 2
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Sulfones: 534
    - 1-(3-(aminomethyl)phenyl)-N-(3-fluoro-2'-(methylsulfonyl)(1,1'-biphenyl)-4-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide: 2

Experts

1.	Knabb, Robert M: 2 articles (12/2002 - 01/2002)
2.	Pinto, Donald J P: 2 articles (12/2002 - 01/2002)
3.	Wong, Pancras C: 2 articles (12/2002 - 01/2002)
4.	Crain, Earl J: 1 article (12/2002)
5.	Lam, Patrick Y: 1 article (12/2002)
6.	Watson, Carol A: 1 article (12/2002)
7.	Wexler, Ruth R: 1 article (12/2002)
8.	Wright, Matthew R: 1 article (12/2002)
9.	Zaspel, Alverna M: 1 article (12/2002)

Related Diseases

1.	Thrombosis (Thrombus) 12/01/2002 - "Therefore, these results suggest that DPC423 is a clinically useful oral anticoagulant for the prevention of arterial thrombosis." 01/01/2002 - "In rabbit and rat models of arteriovenous shunt thrombosis, DPC423 was an effective antithrombotic agent with an IC(50) of 150 and 470 nM, respectively. " 12/01/2002 - "Nonpeptide factor Xa inhibitors III: effects of DPC423, an orally-active pyrazole antithrombotic agent, on arterial thrombosis in rabbits." 12/01/2002 - "The objective of this study was to compare effects of DPC423, enoxaparin (low-molecular-weight heparin), and argatroban (thrombin inhibitor) on arterial thrombosis and hemostasis in rabbit models of electrically induced carotid artery thrombosis and cuticle bleeding, respectively. "
2.	Hemorrhage 12/01/2002 - "The objective of this study was to compare effects of DPC423, enoxaparin (low-molecular-weight heparin), and argatroban (thrombin inhibitor) on arterial thrombosis and hemostasis in rabbit models of electrically induced carotid artery thrombosis and cuticle bleeding, respectively. "
3.	Carotid Artery Thrombosis 12/01/2002 - "The objective of this study was to compare effects of DPC423, enoxaparin (low-molecular-weight heparin), and argatroban (thrombin inhibitor) on arterial thrombosis and hemostasis in rabbit models of electrically induced carotid artery thrombosis and cuticle bleeding, respectively. "

Related Drugs and Biologics

1.	Enoxaparin (Lovenox)
2.	Thrombin
3.	Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)
4.	argatroban (MPQA)
5.	Fibrinolytic Agents (Antithrombotic Agents)
6.	Factor Xa Inhibitors
7.	Anticoagulants
8.	pyrazole