alanyl-glutamyl-aspartyl-glycine

03/01/2002 - "Effect of epithalon on the incidence of chromosome aberrations in senescence-accelerated mice."
11/01/2013 - "As for epithalon, it appears that was shown a pronounced protective effect after treatment, on the test of chromosome aberrations, by reducing both overall mean frequency aberrant cells and indicators for all individuals. "
03/01/2002 - "Treatment with Epithalon (Ala-Glu-Asp-Gly) starting from the age of 2 months decreased the incidence of chromosome aberrations in SAMP-1, SAMR-1, and SHR mice by 20%, 30.1%, and 17.9%, respectively, compared to age-matched controls (p<0.05). "

12/01/2012 - "Epitalon (Ala-Glu-Asp-Gly) proved to be more effective in ME-Arc. "
12/01/2012 - "We have shown that melatonin and the pineal gland peptides (epithalamine and epitalon) exert a correcting influence on the diurnal dynamics of norepinephrine (NE) in the medial preoptic area (MPA) and of dopamine (DA) in the median eminence with arcuate nuclei (ME-Arc) disturbed by single administration of the neurotoxic xenobiotic 1,2-dimethylhydrazine (DMH) in female rats. "

10/01/2003 - "Mitotic activity of tumor cells was significantly inhibited by Epitalon when the treatment was given throughout the experiment (group 2). "
09/08/2002 - "Epitalon inhibited also the development of tumors in jejunum and ileum. "
09/08/2002 - "A trend to decrease the number of tumors in the rectum in rats from groups 2, 3 and 4, treated with Epitalon was found. "
09/01/2002 - "Furthermore, the number of mice bearing 1 mammary tumor was increased, whereas the number of mice bearing 2 or more mammary tumors was reduced in Epitalon-treated in comparison to saline-treated animals (p < 0.05). "
09/01/2002 - "Epitalon treatment reduced the cumulative number and the maximum size of tumors (p < 0.05). "

08/01/2002 - "Epithalon prolonged the lifetime of mice with breast tumors by 1.4 times (p<0.05). "
08/01/2002 - "Epithalon 3.7-fold increased the number of mice without breast tumors (p<0.05), while the number of animals with 6 or more breast tumors decreased by 3 times (p<0.05). "
02/01/2002 - "These results indicate that Epithalon inhibits breast tumor development in transgenic mice, which is probably related to suppression of HER-2/neu expression."
02/01/2002 - "Epithalon inhibits tumor growth and expression of HER-2/neu oncogene in breast tumors in transgenic mice characterized by accelerated aging."
02/01/2002 - "The intensity of HER-2/neu mRNA expression in breast tumors of Epithalon-treated mice was 3.7 times lower than in control animals. "

11/01/2013 - "The aim of this study was a comparative evaluation of the functional parameters of the genome variability in patients with sensitive form of pulmonary tuberculosis before and after treatment, and the possibility of its correction with anti-stress peptide bioregulator - epitalon. "