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carboxymethylpullulan- phenylglycyl- doxorubicin conjugate

structure in first source

Also Known As:

CMPul-FG-DXR

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthacenes
        Anthracyclines: 9423
        Daunorubicin: 2641
        Doxorubicin: 35390
        carboxymethylpullulan-phenylglycyl-doxorubicin conjugate: 1
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthacenes
    - Anthracyclines: 9423
      - Daunorubicin: 2641
        Doxorubicin: 35390
        carboxymethylpullulan-phenylglycyl-doxorubicin conjugate: 1
Carbohydrates: 22023
- Polysaccharides: 15383
  - Glucans: 1624
    - carboxymethylpullulan-phenylglycyl-doxorubicin conjugate: 1
- Glycosides: 2119
  - Aminoglycosides: 5131
    - Anthracyclines: 9423
      - Daunorubicin: 2641
        Doxorubicin: 35390
        carboxymethylpullulan-phenylglycyl-doxorubicin conjugate: 1
Macromolecular Substances: 97
- Polymers: 13051
  - Biopolymers: 773
    - Glucans: 1624
      - carboxymethylpullulan-phenylglycyl-doxorubicin conjugate: 1

Experts

1.	Hamana, H: 1 article (12/2000)
2.	Maekawa, R: 1 article (12/2000)
3.	Nogusa, H: 1 article (12/2000)
4.	Uchida, N: 1 article (12/2000)
5.	Yoshioka, T: 1 article (12/2000)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2000 - "Complete tumor regression followed by long-term tumor-free survival was frequently observed when CMPul-FG-DXR was administered i.v. three times at a dose equivalent to 10 mg / kg of DXR. " 12/01/2000 - "CMPul-FG-DXR may be useful as a cancer chemotherapy agent against solid tumors and metastases." 12/01/2000 - "The antitumor efficacy of the conjugate of doxorubicin (DXR) and carboxymethylpullulan (CMPul) with Phe-Gly spacer (CMPul-FG-DXR) was evaluated using murine tumor models and compared with that of DXR. "
2.	Neoplasm Metastasis (Metastasis) 12/01/2000 - "CMPul-FG-DXR may be useful as a cancer chemotherapy agent against solid tumors and metastases."
3.	Non-Hodgkin Lymphoma (Lymphosarcoma) 12/01/2000 - "The superior survival as well as anti-metastatic effect of CMPul-FG-DXR in comparison with DXR was also demonstrated with the M5076 murine reticulosarcoma model. "
4.	Body Weight (Weight, Body) 12/01/2000 - "Body weight loss in mice treated with the conjugate was less than that in the DXR-treated group, indicating lower systemic toxicity of CMPul-FG-DXR. "

Related Drugs and Biologics

1.	Doxorubicin (Adriamycin)
2.	carboxymethylpullulan
3.	phenylalanylglycine
4.	Antineoplastic Agents (Antineoplastics)