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arglabin-dimethylaminohydrochloride

farnesyltransferase inhibitor; structure in first source

Also Known As:

1,10-epoxy-5,5,7-guaia-3(4),11(13)-dien-6,12-olide-dimethylaminohydrochloride; arglabin-DMA

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Sesquiterpenes: 1370
      - Polycyclic Sesquiterpenes: 9
        Eudesmane Sesquiterpenes: 2
        Guaiane Sesquiterpenes: 5
        arglabin-dimethylaminohydrochloride: 1
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cycloheptanes
        Guaiane Sesquiterpenes: 5
        arglabin-dimethylaminohydrochloride: 1
Polycyclic Compounds: 6
- Polycyclic Sesquiterpenes: 9
  - Eudesmane Sesquiterpenes: 2
    - Guaiane Sesquiterpenes: 5
      - arglabin-dimethylaminohydrochloride: 1

Experts

1.	Adekenov, S M: 1 article (01/2001)
2.	Baker, F L: 1 article (01/2001)
3.	Madden, T L: 1 article (01/2001)
4.	Newman, R: 1 article (01/2001)
5.	Prashad, N: 1 article (01/2001)
6.	Shaikenov, T E: 1 article (01/2001)
7.	Williams, R M: 1 article (01/2001)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2001 - "In primary cultures of human tumor cells, Arglabin-DMA inhibits cell proliferation of a variety of tumor types with IC(90)s in the range of 0.85 to 5.0 microg/ml. Because of these pharmacologic properties, we propose that Arglabin-DMA is suitable for the treatment of ras related malignancies."