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TY 12533

a sodium/proton exchanger inhibitor; structure in first source

Also Known As:

6,7,8,9-tetrahydro-2-methyl-5H-cyclohepta(b)pyridine-3-carbonylguanidine; TY-12533

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amidines: 14
  - Guanidines: 29
    - TY 12533: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - TY 12533: 2

Experts

1.	Aihara, K: 2 articles (05/2001 - 09/2000)
2.	Hisa, H: 2 articles (05/2001 - 09/2000)
3.	Sasamori, J: 2 articles (05/2001 - 09/2000)
4.	Satoh, S: 2 articles (05/2001 - 09/2000)
5.	Yamaguchi, F: 2 articles (05/2001 - 09/2000)
6.	Yoneyama, F: 2 articles (05/2001 - 09/2000)
7.	Satoh, I: 1 article (05/2001)
8.	Kimura, T: 1 article (09/2000)
9.	Kogi, K: 1 article (09/2000)
10.	Mizuno, Y: 1 article (09/2000)

Related Diseases

1.	Ischemia 09/15/2000 - "TY-12533, TY-50893 and cariporide administered before ischemia (0.01-1 mg/kg, i.v.) suppressed the ischemia/reperfusion-induced arrhythmias to the same extent in vivo; but TY-12533 was more effective than cariporide and TY-50893 when they were administered during ischemia (0.1-1 mg/kg). " 05/04/2001 - "These results indicate that TY-12533, even when administered during ischemia, could prevent myocardial stunning without affecting myocardial dysfunction or acidosis induced by brief ischemia."
2.	Myocardial Stunning (Stunned Myocardium) 05/04/2001 - "TY-12533, a novel Na(+)/H(+) exchange inhibitor, prevents myocardial stunning in dogs." 05/04/2001 - "These results indicate that TY-12533, even when administered during ischemia, could prevent myocardial stunning without affecting myocardial dysfunction or acidosis induced by brief ischemia."
3.	Reperfusion Injury 09/15/2000 - "Cardioprotective effect of TY-12533, a novel Na(+)/H(+) exchange inhibitor, on ischemia/reperfusion injury."
4.	Acidosis 05/04/2001 - "These results indicate that TY-12533, even when administered during ischemia, could prevent myocardial stunning without affecting myocardial dysfunction or acidosis induced by brief ischemia."

Related Drugs and Biologics

1.	cariporide