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H 409-22

a neuropeptide Y Y1 receptor antagonist; H 510-45 is the inactive enantiomer; structure in first source

Also Known As:

(2R)-5-((amino(imino)methyl)amino)-2-((2,2-diphenylacetyl)amino)-N-((1R)-1-(4-hydroxyphenyl)ethyl)pentanamide; AR-H0409-22; H 510-45

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - H 409-22: 1

Experts

1.	DiBona, G F: 1 article (08/2001)
2.	Sawin, L L: 1 article (08/2001)

Related Diseases

1.

08/01/2001 - "In conscious severe heart failure rats, high-dose H 409/22 decreased mean arterial pressure by 8 +/- 2 mm Hg but had no effect in normal and mild heart failure rats. "
08/01/2001 - "The glomerular filtration rate, urinary flow rate, and sodium excretion responses to renal sympathetic nerve stimulation were not affected by high-dose H 409/22 in either normal or heart failure rats. "
08/01/2001 - "During graded frequency renal sympathetic nerve stimulation (0 to 10 Hz), high-dose H 409/22 attenuated the decreases in renal blood flow only at 10 Hz (-36% +/- 5%, P <.05) in normal rats but did so at both 4 (-29% +/- 4%, P <.05) and 10 Hz (-33% +/- 5%, P <.05) in heart failure rats. "

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