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Org 36764

an antithrombin III and thrombin binding glycoconjugate; structure in first source

Also Known As:

Org36764

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Glycoconjugates: 1353
  - Org 36764: 1

Experts

1.	Meuleman, D G: 1 article (10/2000)
2.	Tromp, M: 1 article (10/2000)
3.	Vogel, G M: 1 article (10/2000)
4.	van Amsterdam, R G: 1 article (10/2000)
5.	van Dinther, T G: 1 article (10/2000)

Related Diseases

1.	Thrombosis (Thrombus) 10/01/2000 - "The results indicate that the novel drug Org 36764 is a drug with antithrombotic potential against venous and arterial thrombosis." 10/01/2000 - "Org 36764 was more active in suppressing in vivo thrombus formation on stents than UFH. " 10/01/2000 - "Org 36764 was more active than the pentasaccharide SanOrg 34006 (= AT binding domain of Org 36764) in arterial thrombosis, but both were equally active in venous thrombosis. " 10/01/2000 - "In arterial thrombosis following endothelial damage by ferric chloride, Org 36764 was more active than the LMW heparin enoxaparin and SanOrg 34006 and similar active to UFH. "
2.	Venous Thrombosis (Deep-Vein Thrombosis) 10/01/2000 - "Org 36764 was more active than the pentasaccharide SanOrg 34006 (= AT binding domain of Org 36764) in arterial thrombosis, but both were equally active in venous thrombosis. "
3.	Thrombocytopenia (Thrombopenia) 10/01/2000 - "It displays in buffer an anti-Xa and anti-thrombin activity of 415 and 2 U/mg, respectively, compared to 172 and 114 U/mg, respectively, for unfractionated heparin (UFH), Org 36764 does not cross-react with HIT (heparin induced thrombocytopenia) antibodies and is not neutralised by PF4. "

Related Drugs and Biologics

1.	Enoxaparin (Lovenox)
2.	Thrombin
3.	Heparin (Liquaemin)
4.	Buffers
5.	Antibodies
6.	idraparinux
7.	ferric chloride

Related Therapies and Procedures

1.	Stents