polysaccharide MGN3

an arabinoxylan extracted from rice bran that is treated enzymatically with an extract from shitake mushrooms; activates human natural killer (NK) cell function in vivo and in vitro; Biobran is a tradename

Also Known As:

Networked: 31 relevant articles (5 outcomes, 17 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ghoneum, Mamdooh: 14 articles (11/2021 - 11/2003)
2.	Badr El-Din, Nariman K: 7 articles (06/2020 - 01/2008)
3.	Ghoneum, M: 4 articles (02/2020 - 09/2004)
4.	Ali, Doaa A: 3 articles (06/2020 - 01/2014)
5.	Shaheen, Magda: 3 articles (03/2018 - 12/2010)
6.	Gollapudi, Sastry: 3 articles (01/2008 - 11/2003)
7.	Elsaid, Ahmed F: 2 articles (11/2021 - 03/2018)
8.	Pan, Deyu: 2 articles (12/2016 - 12/2010)
9.	Noaman, Eman: 2 articles (09/2008 - 01/2008)
10.	Agrawal, Anshu: 1 article (11/2021)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2018 - "Systematic search of journal databases and gray literature for primary studies reporting the effects of MGN-3 on cancer and cancer treatment. " 11/22/2019 - "Final tumor weight was suppressed by 46% for Biobran, 31% for Rad and 57% for the combined treatment (Biobran + Rad) relative to control untreated mice. " 01/01/2018 - "In murine models, MGN-3 has been shown to act against carcinogenic agents, and inhibit tumor growth, either by itself or in combination with other anticancer compounds. " 08/01/2016 - "These data suggest that MGN-3 supplementation enhances tumor cell demise in the presence of a low dose of chemotherapeutic agent via apoptotic mechanism." 10/01/2014 - "Tumor lysate-pulsed MGN-3 DC also increased tumor cell killing compared to DC-stimulated CD8+ T cells. "
2.	Carcinogenesis 06/01/2020 - "Biobran may be a promising chemopreventive and chemotherapeutic agent for liver carcinogenesis." 12/01/2016 - "We conclude that Biobran provides protection against chemical induction of glandular stomach carcinogenesis in rats and may be useful for the treatment of human patients with gastric cancer." 12/01/2016 - "Chemopreventive Activity of MGN-3/Biobran Against Chemical Induction of Glandular Stomach Carcinogenesis in Rats and Its Apoptotic Effect in Gastric Cancer Cells." 12/01/2016 - "In the current study, we investigated the chemopreventive activity of arabinoxylan rice bran, MGN-3/Biobran, against chemical induction of glandular stomach carcinogenesis in rats. " 06/01/2020 - "Chemopreventive role of arabinoxylan rice bran, MGN-3/Biobran, on liver carcinogenesis in rats."
3.	Infections 12/01/2016 - "Our finding of Biobran's efficacy against HCV infection warrants further investigation in multiple clinical trials (Clinical Trials Registration: NCT02690103)." 09/01/2004 - "This data demonstrates that MGN-3 is a potent inducer of phagocytic function by macrophage, and suggests that MGN-3 is a useful agent for fighting microbial infection." 12/01/2016 - "Arabinoxylan rice bran (Biobran) suppresses the viremia level in patients with chronic HCV infection: A randomized trial."
4.	Hepatocellular Carcinoma (Hepatoma) 12/01/2010 - "MGN-3 in conjunction with IT may be useful for the treatment of hepatocellular carcinoma and warrants further investigation in multiple clinical trials."
5.	Stomach Neoplasms (Stomach Cancer) 12/01/2016 - "We conclude that Biobran provides protection against chemical induction of glandular stomach carcinogenesis in rats and may be useful for the treatment of human patients with gastric cancer." 12/01/2016 - "Chemopreventive Activity of MGN-3/Biobran Against Chemical Induction of Glandular Stomach Carcinogenesis in Rats and Its Apoptotic Effect in Gastric Cancer Cells." 12/01/2016 - "Gastric cancer was induced by carcinogen methylnitronitrosoguanidine (MNNG), and rats received MNNG alone or MNNG plus Biobran (40 mg/kg body weight) for a total of 8 months. "

Related Drugs and Biologics

1.	Caspase 3 (Caspase-3)
2.	Carcinogens
3.	NF-kappa B (NF-kB)
4.	Messenger RNA (mRNA)
5.	Collagen
6.	NF-KappaB Inhibitor alpha
7.	arabinoxylan
8.	Death Domain Receptors
9.	Paclitaxel (Taxol)
10.	Daunorubicin (Cerubidine)

Related Therapies and Procedures

1.	Radiotherapy
2.	Intraperitoneal Injections
3.	Therapeutics