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prednisolone 21-((4'-nitrooxymethyl)benzoate)

structure in first source

Also Known As:

21-NO-prednisolone; NCX 1015; NCX-1015; NCX1015

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Pregnanes: 9
      - Pregnadienes
        Pregnadienetriols
        Prednisolone: 12013
        prednisolone 21-((4'-nitrooxymethyl)benzoate): 6

Experts

1.	Flower, Roderick J: 3 articles (09/2003 - 02/2002)
2.	Perretti, Mauro: 3 articles (09/2003 - 02/2002)
3.	Paul-Clark, Mark J: 2 articles (09/2003 - 02/2002)
4.	Flower, R J: 2 articles (05/2003 - 12/2000)
5.	Perretti, M: 2 articles (05/2003 - 12/2000)
6.	Del Soldato, Piero: 2 articles (11/2002 - 02/2002)
7.	Aden, Sadia A: 1 article (11/2005)
8.	Bachis, Alessia: 1 article (11/2005)
9.	Brandoli, Cinzia: 1 article (11/2005)
10.	Mallei, Alessandra: 1 article (11/2005)

Related Diseases

1.	Inflammation (Inflammations) 02/05/2002 - "Dosing of rats with NCX-1015 (0.4-4 micromol/kg, i.p.) greatly reduced all parameters of inflammation. " 12/01/2000 - "4. In a chronic model of granulomatous tissue inflammation, administration of NCX-1015 (13.9 micromol kg(-1)) from day 1 (i.e. " 11/26/2002 - "In vivo treatment with NCX-1015 potently stimulated IL-10 production, suggesting that the NO steroid induces a regulatory subset of T cells that negatively modulates intestinal inflammation." 12/01/2000 - "5. In conclusion we show that NCX-1015 is more potent than prednisolone in controlling several, though not all, parameters of acute and chronic inflammation, and propose that this effect may be due to a co-operation between the steroid moiety and nitric oxide or related species released in biological fluids. "
2.	Peritonitis 09/15/2003 - "Accordingly, NCX-1015, but not prednisolone or other derivatives, produced a rapid inhibition of the early neutrophil recruitment and mediator generation in a model of peritonitis. " 12/01/2000 - "3. In the zymosan peritonitis model, NCX-1015 was more active than prednisolone in suppressing neutrophil extravasation (ED(50) of 5.5 and 25.8 micromol kg(-1), respectively), nitrite accumulation (ED(50) of 1.38 and 22.2 micromol kg(-1), respectively) and release of the chemokine KC (ED(50) of 5.5 and 27.7 micromol kg(-1), respectively) as determined at the 4 h time-point. "
3.	Arthritis (Polyarthritis) 05/01/2003 - "In the collagen II-induced arthritis model, NCX-1015 abrogated the plasma levels of a catabolite of cartilage and bone metabolism, indication of a disease modifying action. " 02/05/2002 - "Potent antiarthritic properties of a glucocorticoid derivative, NCX-1015, in an experimental model of arthritis."
4.	Spinal Cord Injuries (Spinal Cord Injury) 11/16/2005 - "The nitrosteroid NCX 1015, a prednisolone derivative, improves recovery of function in rats after spinal cord injury."
5.	Colitis 11/26/2002 - "NCX-1015, a nitric-oxide derivative of prednisolone, enhances regulatory T cells in the lamina propria and protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice."

Related Drugs and Biologics

1.	Prednisolone (Predate)
2.	Steroids
3.	Nitric Oxide (Nitrogen Monoxide)
4.	Chemokines
5.	Interleukin-10 (Interleukin 10)
6.	Zymosan
7.	Sulfonic Acids
8.	Nitrites
9.	Glucocorticoids
10.	Collagen