CX 659S

structure in first source

Also Known As:

CX-659S; 2H-1-Benzopyran-2-carboxamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (2S)-

Networked: 10 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidinones: 71
      - Uracil: 1493
        CX 659S: 10

Experts

1.	Hayashi, Hideya: 5 articles (11/2003 - 03/2002)
2.	Inoue, Yoshifumi: 4 articles (11/2003 - 10/2002)
3.	Isobe, Masakazu: 3 articles (11/2003 - 01/2003)
4.	Tsuchiya, Masami: 3 articles (11/2003 - 03/2002)
5.	Goto, Y: 3 articles (10/2002 - 08/2000)
6.	Hayashi, H: 3 articles (10/2002 - 08/2000)
7.	Isobe, Yoshiaki: 2 articles (11/2003 - 10/2002)
8.	Tobe, Masanori: 2 articles (11/2003 - 10/2002)
9.	Furue, Masutaka: 2 articles (06/2003 - 03/2002)
10.	Uchi, Hiroshi: 2 articles (06/2003 - 03/2002)

Related Diseases

1.	Atopic Dermatitis (Atopic Eczema) 12/01/2000 - "CX-659S thus could be a useful therapeutic agent for allergic cutaneous disorders such as allergic contact dermatitis and atopic dermatitis." 06/01/2003 - "CX-659S, a newly discovered anti-inflammatory compound, exerts inhibitory effects on chronic contact hypersensitivity responses (CHRs) induced by repeated application with picryl chloride (PC), which is known to mimic many, if not all, events occurring within lesional skin of patients with atopic dermatitis (AD). " 05/01/2010 - "Increased sprouting of epidermal nerve fibers of lesional skin are thought to be associated with persistent pruritus in chronic inflammatory dermatitis such as atopic dermatitis as supported by a murine study using tacrolimus (or FK506: FK) which was shown to inhibit both epidermal sprouting of nerves and scratching behavior or by immunohistochemical observations of lesional skin in the patients with atopic dermatitis or prurigo, etc. To examine a mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 (MEK1/2) inhibitor (CX-659S: CX) for a possible anti-pruritic property in vivo since some MEK1/2 inhibitors have been reported to inhibit neurite growth in vitro. "
2.	Hypersensitivity (Allergy) 08/01/2000 - "Synthesis and biological evaluation of CX-659S and its related compounds for their inhibitory effects on the delayed-type hypersensitivity reaction." 01/01/2003 - "The present study was conducted to determine the combined effect of topical CX-659S with topical corticosteroid on immediate type (ITR), late type (LTR), and delayed type hypersensitivity (DTHR) allergic reactions that are involved in AD. "
3.	Dermatitis 10/01/2002 - "CX-659S (1) [(S)-6-amino-5-(6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxamido)-3-methyl-1-phenyl-2,4-(1H,3H)-pyrimidinedione], has been developed as a new type anti-inflammatory agent for the treatment of dermatitis. " 05/01/2010 - "Increased sprouting of epidermal nerve fibers of lesional skin are thought to be associated with persistent pruritus in chronic inflammatory dermatitis such as atopic dermatitis as supported by a murine study using tacrolimus (or FK506: FK) which was shown to inhibit both epidermal sprouting of nerves and scratching behavior or by immunohistochemical observations of lesional skin in the patients with atopic dermatitis or prurigo, etc. To examine a mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 (MEK1/2) inhibitor (CX-659S: CX) for a possible anti-pruritic property in vivo since some MEK1/2 inhibitors have been reported to inhibit neurite growth in vitro. "
4.	Pruritus (Itching) 05/01/2010 - "Increased sprouting of epidermal nerve fibers of lesional skin are thought to be associated with persistent pruritus in chronic inflammatory dermatitis such as atopic dermatitis as supported by a murine study using tacrolimus (or FK506: FK) which was shown to inhibit both epidermal sprouting of nerves and scratching behavior or by immunohistochemical observations of lesional skin in the patients with atopic dermatitis or prurigo, etc. To examine a mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 (MEK1/2) inhibitor (CX-659S: CX) for a possible anti-pruritic property in vivo since some MEK1/2 inhibitors have been reported to inhibit neurite growth in vitro. "
5.	Prurigo 05/01/2010 - "Increased sprouting of epidermal nerve fibers of lesional skin are thought to be associated with persistent pruritus in chronic inflammatory dermatitis such as atopic dermatitis as supported by a murine study using tacrolimus (or FK506: FK) which was shown to inhibit both epidermal sprouting of nerves and scratching behavior or by immunohistochemical observations of lesional skin in the patients with atopic dermatitis or prurigo, etc. To examine a mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 (MEK1/2) inhibitor (CX-659S: CX) for a possible anti-pruritic property in vivo since some MEK1/2 inhibitors have been reported to inhibit neurite growth in vitro. "

Related Drugs and Biologics

1.	Adrenal Cortex Hormones (Corticosteroids)
2.	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)
3.	Mitogen-Activated Protein Kinases
4.	Tacrolimus (Prograf)
5.	Phosphotransferases (Kinase)
6.	Picryl Chloride (Trinitrochlorobenzene)
7.	Oxazolone
8.	Dinitrochlorobenzene (DNCB)
9.	Arachidonic Acid (Vitamin F)
10.	Cyclosporine (Ciclosporin)

Related Therapies and Procedures

1.	Therapeutics