petasin

both petasin and neopetasin inhibit biosynthesis of cysteinyl-leukotriene; unlike petasin, neopetasin does not inhibit eosinophil cation protein releasenor suppresses cPLA2 activity; from Petasites formosanus Kitamurai; structure in first source

Also Known As:

(1R,2R,7R,8aR)-7-Isopropenyl-1,8a-dimethyl-6-oxo-1,2,3,4,6,7,8,8a-octahydro-2-naphthalenyl (2Z)-2-methyl-2-butenoate; (1R,2R,7S,8aR)-7-Isopropenyl-1,8a-dimethyl-6-oxo-1,2,3,4,6,7,8,8a-octahydro-2-naphthalenyl (2Z)-3-(methylsulfanyl)acrylate; S-petasin; neopetasin; 2-Butenoic acid, 2-methyl-, (1R,2R,7S,8aR)-1,2,3,4,6,7,8,8a-octahydro-1,8a-dimethyl-7-(1-methylethenyl)-6-oxo-2-naphthalenyl ester, (2Z)-

Networked: 19 relevant articles (1 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Sesquiterpenes: 1370
      - petasin: 19

Experts

1.	Lin, Yun-Lian: 4 articles (01/2011 - 12/2002)
2.	Wang, Paulus S: 3 articles (01/2015 - 12/2002)
3.	Choi, Young Whan: 2 articles (10/2020 - 06/2020)
4.	Guo, Lu: 2 articles (10/2020 - 06/2020)
5.	Kang, Jum Soon: 2 articles (10/2020 - 06/2020)
6.	Kang, Nam Jun: 2 articles (10/2020 - 06/2020)
7.	Chang, Ling-Ling: 2 articles (04/2004 - 12/2002)
8.	Wun, Wan-Song Alfred: 2 articles (04/2004 - 12/2002)
9.	Hakozaki, Mayuka: 1 article (03/2022)
10.	Kanno, Yuko: 1 article (03/2022)

Related Diseases

1.	Metabolic Diseases (Metabolic Disease) 06/27/2014 - "The preclinical data suggested that petasin (1) could be useful for the treatment of metabolic diseases in humans. "
2.	Neoplasms (Cancer) 05/05/2019 - "The present study aimed to investigate the anticolon cancer activity of petasin both in vitro and in vivo. " 05/05/2019 - "In vivo, 10 mg/kg petasin inhibited tumor growth in Balb/c nude mice (924.18 ± 101.23 vs. 577.67 ± 75.12 mm at day 28, P = 0.001) and induced apoptosis (3.6 ± 0.7% vs. 36.0 ± 4.9%, P = 0.001) in tumor tissues. " 05/05/2019 - "Finally, in vivo activity of petasin was evaluated using the SW-620 subcutaneous tumor model established in Balb/c nude mice. " 01/01/2021 - "Petasin potently inhibits mitochondrial complex I-based metabolism that supports tumor growth and metastasis." 01/01/2015 - "Petasin (Petasides hybridus) is a perennial shrub that is found in Europe as well as parts of Asia and North America and is being used to treat hypertension, tumors and asthma. "
3.	Migraine Disorders (Migraine) 07/01/2016 - "These results suggest that grape pomace and ginger extracts, and S-petasin may have anti-inflammatory propensity by preventing CGRP release in migraine, although potentially by different mechanisms, which future studies may elucidate further. " 07/01/2016 - "S-petasin was selected as a suspected active constituent of butterbur extract, the migraine prophylactic dietary supplement. " 11/01/2021 - "Petasites hybridus contains petasin which possesses anti-inflammatory property used in treatment of migraine and allergic rhinitis. " 04/13/2021 - "Butterbur root extract with its active ingredients petasin and isopetasin has been used in the prophylactic treatment of migraine for years, while its sites of action are not completely clear. " 01/01/2020 - "Ginkgolide B, melatonin, histamine, oxytocin, various ribosomal peptide toxins, kavalactones, devil's claw-derived compounds, salvinorin A and petasin are among those agents that show considerable promise as novel drugs in migraine prevention and treatment. "
4.	Asthma (Bronchial Asthma) 01/01/2011 - "In conclusion, the present results for S-petasin at least partially explain why Petasites formosanus is used as a folk medicine to treat asthma in Taiwan." 01/01/2015 - "In an ovalbumin-induced mouse asthma model, s-petasin significantly inhibited the accumulations of eosinophils, macrophages, and lymphocytes in bronchoalveolar fluids. " 01/01/2015 - "Petasin (Petasides hybridus) is a perennial shrub that is found in Europe as well as parts of Asia and North America and is being used to treat hypertension, tumors and asthma. " 01/01/2015 - "This study shows that s-petasin in Petasites genus has therapeutic effects on allergic and inflammatory diseases, such as, asthma and peritonitis through degranulation inhibition in mast cells, suppression of iNOS induction and production of NO in macrophages, and suppression of inflammatory cell accumulation. " 01/01/2015 - "Therapeutic effects of s-petasin on disease models of asthma and peritonitis."
5.	Carcinoma (Carcinomatosis) 05/05/2019 - "Petasin significantly inhibited the proliferation of human colon carcinoma cell lines, induced apoptosis, and suppressed migration and invasion in SW-620 cells. " 05/05/2019 - "Inhibitory effects of petasin on human colon carcinoma cells mediated by inactivation of Akt/mTOR pathway." 01/01/2015 - "In a previous study, we reported that petasin possesses biological effects including inhibition of testosterone production and the release of corticosterone from rat zona fasciculata-reticularis cells, and anti-proliferative effect on human T24 bladder carcinoma cells. "

Related Drugs and Biologics

1.	Corticosterone
2.	Therapeutic Uses
3.	Oleic Acid (Oleate)
4.	Testosterone (Sustanon)
5.	Hormones (Hormone)
6.	Anti-Allergic Agents (Antiallergic Agents)
7.	Sesquiterpenes
8.	Ovalbumin
9.	isopetasin
10.	Caspase 7

Related Therapies and Procedures

1.	Therapeutics
2.	Traditional Medicine (Folk Remedies)