((3- ((2R)- (((2R)- 3- chlorophenyl)- 2- hydroxyethyl)amino)propyl)- 1H- indol- 7- yloxy)acetic acid

TAK-677 is also reported as AJ-9677

Also Known As:

(3-((2R)-(((2R)-(3-chlorophenyl)-2-hydroxyethyl)amino)propyl)-1H-indol-7-yloxy)acetic acid; 3-CP-2-HE-API-AA; AJ 9677; AJ-9677; AJ9677; TAK-677

Networked: 5 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Acetates: 4994
      - ((3-((2R)-(((2R)-3-chlorophenyl)-2-hydroxyethyl)amino)propyl)-1H-indol-7-yloxy)acetic acid: 5
Lipids: 114793
- Fatty Acids: 27405
  - Volatile Fatty Acids: 3052
    - Acetates: 4994
      - ((3-((2R)-(((2R)-3-chlorophenyl)-2-hydroxyethyl)amino)propyl)-1H-indol-7-yloxy)acetic acid: 5
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - ((3-((2R)-(((2R)-3-chlorophenyl)-2-hydroxyethyl)amino)propyl)-1H-indol-7-yloxy)acetic acid: 5

Experts

1.	Kimura, K: 2 articles (10/2008 - 08/2007)
2.	Omachi, A: 2 articles (10/2008 - 08/2007)
3.	Saito, M: 2 articles (10/2008 - 08/2007)
4.	Hasebe, Ko: 1 article (12/2008)
5.	Matsumoto, Rikiya: 1 article (12/2008)
6.	Otsuka, Atsushi: 1 article (12/2008)
7.	Ozono, Seiichiro: 1 article (12/2008)
8.	Shinbo, Hitoshi: 1 article (12/2008)
9.	Matsushita, Y: 1 article (10/2008)
10.	Ishioka, K: 1 article (08/2007)

Related Diseases

1.	Obesity 08/01/2007 - "It was concluded that AJ-9677 is useful for the treatment of obesity in the dog." 10/01/2008 - "To evaluate the role of UCP1 in the anti-obesity effect of the agonists, we isolated adipocytes from subcutaneous fat pad of beagles before and after a 2-week treatment with AJ-9677, a specific beta3-adrenoceptor agonist, and examined their thermogenic activity in vitro. " 08/01/2007 - "A selective beta3-adrenoceptor agonist, AJ-9677, was reported to ameliorate obesity and insulin resistance in KK-Ay mice. " 11/01/2002 - "TAK-677 is a beta3-adrenergic agonist under development by Dainippon and Takeda for the potential treatment of non-insulin dependent diabetes and obesity. "
2.	Insulin Resistance 01/01/2001 - "The mechanism by which the specific beta3-adrenoceptor agonist AJ-9677 relieves insulin resistance in vivo was investigated by studying its effects in the white and brown adipose tissues of the KK-Ay/Ta diabetic obese mouse model. " 01/01/2001 - "Mechanism of amelioration of insulin resistance by beta3-adrenoceptor agonist AJ-9677 in the KK-Ay/Ta diabetic obese mouse model." 08/01/2007 - "A selective beta3-adrenoceptor agonist, AJ-9677, was reported to ameliorate obesity and insulin resistance in KK-Ay mice. " 01/01/2001 - "The generation of small adipocytes, presumably mediated by increased expression of UCP-1 in addition to increased lipolysis in response to AJ-9677, was associated with decreased TNF-alpha and free fatty acid production and may be the mechanism of amelioration of insulin resistance in KK-Ay/Ta diabetic obese mice."
3.	Overactive Urinary Bladder (Overactive Bladder) 12/01/2008 - "AJ-9677 has a high relaxant potency on the rat, monkey and human detrusor smooth muscle, and it may have the potential to treat overactive bladder."
4.	Body Weight (Weight, Body) 08/01/2007 - "Daily treatment of AJ-9677 at a lower dose (0.01 mg/kg) for three weeks produced no notable change in body weight, but at a higher dose (0.1 mg/kg) it reduced the body weight compared to a placebo treatment after seven weeks. "

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