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NPC 14686

Also Known As:

Fmoc-L-homophenylalanine; NPC-14686; NPC14686

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Butyrates: 2613
      - Aminobutyrates: 1253
        NPC 14686: 4
Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Aminobutyrates: 1253
    - NPC 14686: 4

Experts

1.	Jan, Chung-Ren: 4 articles (10/2015 - 04/2003)
2.	Chou, Chiang-Ting: 3 articles (10/2015 - 01/2006)
3.	Chang, Hong-Tai: 2 articles (10/2015 - 01/2006)
4.	Ho, Chin-Man: 2 articles (10/2015 - 06/2014)
5.	Kuo, Chun-Chi: 2 articles (10/2015 - 06/2014)
6.	Kuo, Daih-Huang: 2 articles (10/2015 - 06/2014)
7.	Liang, Wei-Zhe: 2 articles (10/2015 - 06/2014)
8.	Shieh, Pochuen: 2 articles (10/2015 - 06/2014)
9.	Chen, Fu-An: 1 article (10/2015)
10.	Fang, Yi-Chien: 1 article (10/2015)

Related Diseases

1.	Osteosarcoma (Osteogenic Sarcoma) 06/30/2014 - "The effect of NPC-14686 on cytosolic Ca²⁺ concentrations ([Ca²⁺]i) and viability in MG63 human osteosarcoma cells was explored. " 06/30/2014 - "Together, in human osteosarcoma cells, NPC-14686 induced a [Ca²⁺]i rise by inducing phospholipase C-dependent Ca²⁺ release from the endoplasmic reticulum and Ca²⁺ entry via protein kinase C-sensitive store-operated Ca²⁺ channels. "
2.	Prostatic Neoplasms (Prostate Cancer) 01/25/2006 - "NPC-14686 may be cytotoxic to prostate cancer cells." 01/25/2006 - "These findings suggest that in human PC3 prostate cancer cells, NPC-14686 increases [Ca2+]i by evoking extracellular Ca2+ influx and releasing intracellular Ca2+ from the endoplasmic reticulum via a phospholiase C-independent manner. " 01/25/2006 - "NPC-14686 (Fmoc-l-homophenylalanine)-induced CaCa2+ increases and death in human prostate cancer cells." 01/25/2006 - "The effect of NPC-14686, a potential anti-inflammatory drug, on cytosolic free Ca2+ levels ([Ca2+]i) and growth in PC3 human prostate cancer cells was examined by using fura-2 as a fluorescent Ca2+ indicator and WST-1 as a fluorescent growth dye. "
3.	Mouth Neoplasms (Oral Cancer) 10/31/2015 - "The effect of the anti-inflammatory compound NPC-14686 on intracellular Ca²⁺ concentration ([Ca²⁺](i)) and viability in OC2 human oral cancer cells was investigated. " 10/31/2015 - "Effect of NPC-14686 (Fmoc-l-Homophenylalanine) on Ca²⁺ Homeostasis and Viability in OC2 Human Oral Cancer Cells."
4.	Hepatocellular Carcinoma (Hepatoma) 04/25/2003 - "Together, the results suggest that in human hepatoma cells, NPC-14686 induced a [Ca(2+)](i) increase by causing store Ca(2+) release from the endoplasmic reticulum in an phospholipase C-independent manner, and by inducing nifedipine-sensitive Ca(2+) influx." 04/25/2003 - "The effect of NPC-14686, a potential anti-inflammatory drug, on cytosolic free Ca(2+) levels ([Ca(2+)](i)) in HA22/VGH human hepatoma cells was explored by using fura-2 as a fluorescent Ca(2+) indicator. " 04/25/2003 - "Effect of NPC-14686 (Fmoc-L-homophenylalanine) on intracellular Ca2+ levels in human hepatoma cells."

Related Drugs and Biologics

1.	NPC 14686
2.	Fura-2 (Fura 2)
3.	Type C Phospholipases
4.	Indicators and Reagents (Reagents)
5.	Protein Kinase C
6.	Nifedipine (Adalat)
7.	Coloring Agents (Dyes)