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CNS 1261

a potential SPECT agent for imaging NMDA receptor activation; structure in first source

Also Known As:

CNS-1261; N-(1-naphthyl)-N'-(3-iodophenyl)-N'-methylguanidine

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amidines: 14
  - Guanidines: 29
    - CNS 1261: 2

Experts

1.	Bressan, Rodrigo A: 1 article (07/2005)
2.	Ell, Peter J: 1 article (07/2005)
3.	Erlandsson, Kjell: 1 article (07/2005)
4.	Krystal, John H: 1 article (07/2005)
5.	Mulligan, Rachel S: 1 article (07/2005)
6.	Pilowsky, Lyn S: 1 article (07/2005)
7.	Stone, James M: 1 article (07/2005)
8.	Durant, G J: 1 article (08/2000)
9.	Kodama, K: 1 article (08/2000)
10.	Magar, S S: 1 article (08/2000)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 07/01/2005 - "Impact of schizophrenia and chronic antipsychotic treatment on [123I]CNS-1261 binding to N-methyl-D-aspartate receptors in vivo." 07/01/2005 - "We used [123I]CNS-1261 to determine whether binding to the NMDA receptor intrachannel PCP/MK-801 site is affected by schizophrenia or by treatment with typical antipsychotics and clozapine in vivo. "
2.	Brain Ischemia (Cerebral Ischemia) 08/01/2000 - "Radiolabeled CNS 1261 appears to be a good candidate for further development as a single photon emission computed tomography tracer in the investigation of NMDA receptor activation in cerebral ischemia."

Related Drugs and Biologics

1.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)
2.	Dizocilpine Maleate (Dizocilpine)
3.	Antipsychotic Agents (Antipsychotics)
4.	Clozapine (Clozaril)