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3- (3- chloro- 4- hydroxyphenylamino)- 4- (4- nitrophenyl)- 1H- pyrrole- 2,5- dione

a glycogen synthase kinase-3 inhibitor; structure in first source

Also Known As:

SB 415286; SB-415286; SB415286

Networked: 13 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Camins, Antoni: 2 articles (09/2009 - 05/2008)
2.	Folch, Jaume: 2 articles (09/2009 - 05/2008)
3.	Pallàs, Mercè: 2 articles (09/2009 - 05/2008)
4.	Pizarro, Javier G: 2 articles (09/2009 - 05/2008)
5.	Chiu, Ying-Ming: 1 article (01/2018)
6.	Chou, Shen-Chieh: 1 article (01/2018)
7.	Hsieh, Chin-Tung: 1 article (01/2018)
8.	Kao, Jung-Ta: 1 article (01/2018)
9.	Lee, Yi-Ju: 1 article (01/2018)
10.	Shieh, Dong-Chen: 1 article (01/2018)

Related Diseases

1.	Neuroinflammatory Diseases 11/01/2013 - "These results confirmed that GSK-3β inhibitor LiCl and SB415286 provide protection against neuroinflammation in 6-OHDA-treated astrocytes. "
2.	Neuroblastoma 09/01/2009 - "A molecular study of pathways involved in the inhibition of cell proliferation in neuroblastoma B65 cells by the GSK-3 inhibitors lithium and SB-415286." 09/01/2009 - "We examined the antiproliferative effects of two GSK-3 inhibitors, lithium and SB-415286, on B65 neuroblastoma cell line. " 05/01/2008 - "Neuroprotective effects of SB-415286 on hydrogen peroxide-induced cell death in B65 rat neuroblastoma cells and neurons."
3.	Necrosis 07/15/2014 - "Mice treated with SB415286 showed significant protection from radiation-induced necrosis, as determined by in vivo MRI with histologic validation. " 07/15/2014 - "Effectiveness of SB415286 as a neuroprotectant against necrosis motivates potential clinical trials of it or other GSK-3β inhibitors." 07/15/2014 - "To quantify the effectiveness of SB415286, a specific inhibitor of GSK-3β, as a neuroprotectant against radiation-induced central nervous system (brain) necrosis in a mouse model. "
4.	Stomach Neoplasms (Stomach Cancer) 02/24/2006 - "Furthermore, inhibition of glycogen synthase kinase-3beta (GSK-3beta) by SB415286 induced expression of COX-2 mRNA and protein as well as the enzyme activity in the gastric cancer cells. "
5.	Shock 03/01/2006 - "The effects of the inhibitors of glycogen synthase kinase-3beta (GSK-3beta), TDZD-8 and SB 415286, which can substantially reduce the systemic inflammation associated with endotoxic shock in vivo, have now been investigated on the acute colitis provoked by trinitrobenzene sulphonic acid (TNBS) in the rat. "

Related Drugs and Biologics

1.	Glycogen Synthase Kinase 3
2.	Lithium
3.	Neuroprotective Agents
4.	beta Catenin
5.	Proteins (Proteins, Gene)
6.	Glycogen Synthase (Synthase I)
7.	Glycogen Synthase Kinase 3 beta
8.	SB 216763
9.	Glycogen Synthase Kinases
10.	Small Interfering RNA (siRNA)

Related Therapies and Procedures

1.	Ischemic Postconditioning