HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

WHI P97

inhibits janus kinase 3; structure in first source

Also Known As:

4-(3',5'-dibromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline; WHI-P97

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinazolines: 402
      - WHI P97: 4

Experts

1.	Liu, X P: 2 articles (05/2001 - 12/2000)
2.	Uckun, F M: 2 articles (05/2001 - 12/2000)
3.	Leong, Khai Pang: 1 article (03/2004)
4.	Wong, W S Fred: 1 article (03/2004)
5.	Ghosh, S: 1 article (05/2001)
6.	Mao, C: 1 article (05/2001)
7.	Narla, R K: 1 article (05/2001)
8.	Navara, C S: 1 article (05/2001)
9.	Sudbeck, E A: 1 article (05/2001)
10.	Vassilev, A O: 1 article (05/2001)

Related Diseases

1.	Asthma (Bronchial Asthma) 12/01/2000 - "Further development of WHI-P97 may therefore provide the basis for new and effective treatment as well as prevention programs for allergic asthma in clinical settings." 12/01/2000 - "Notably, WHI-P97 showed promising biological activity in a mouse model of allergic asthma at nontoxic dose levels. " 03/11/2004 - "genistein, tyrphostin AG213, piceatannol, tyrphostin AG490, WHI-P97, WHI-P131, Syk antisense) in animal models of allergic asthma have been reported. "
2.	Respiratory Hypersensitivity 12/01/2000 - "Treatment of ovalbumin-sensitized mice with WHI-P97 prevented the development of airway hyper-responsiveness to methacholine in a dose-dependent fashion. "
3.	Neoplasms (Cancer) 10/01/1999 - "WHI-P97 effectively inhibited the in vitro invasiveness of EGFR-positive human cancer cells in a concentration-dependent manner. "
4.	Breast Neoplasms (Breast Cancer) 05/01/2001 - "Both LFM-A12 and WHI-P97 inhibit the in vitro invasiveness of EGFR positive human breast cancer cells at micromolar concentrations and induce apoptotic cell death. "

Related Drugs and Biologics

1.	Tyrphostins
2.	Genistein
3.	Methacholine Chloride (Methacholine)
4.	Ovalbumin
5.	LFM A12
6.	WHI P131
7.	alpha- cyano- (3,4- dihydroxy)- N- benzylcinnamide
8.	tyrphostin 47
9.	3,3',4,5'-tetrahydroxystilbene